| 0 | * Obama * The First 100 Minutes | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson; colors: Mark Fredrickson | Barack Obama; Alfred E. Neuman |
| 2 | Departments | table of contents | 1 | pencils: various; inks: various; letters: typeset | Alfred E. Neuman; Barack Obama; Hillary Clinton; Monroe; Monroe's mother; Anderson Cooper |
| 3 | Random Samplings of Reader Mail | letters page | 2.67 | script: John Ficarra, Jon Scieszka; pencils: Bob Thaves; inks: Bob Thaves | Alfred E. Neuman; Cindy Hodgson; Barry Halkin; Jed E. Neuman; Jon Scieszka; John Hodgman; James Klausmeyer; Frank; Ernest; David Wain; Kenneth Mok |
| 4 | - | credits, title page | 0.33 | letters: typeset | |
| 6 | The Fundalini Pages | comic story | 3 | script: various; pencils: various; inks: various; letters: typeset | Tyra Banks; Melvin; Jenkins; Barack Obama; Michelle Obama; Alfred E. Neuman; Dilbert; Grimmy; Beetle Bailey; Garfield |
| 7 | Special Giveaway And Contest! | promo (ad from the publisher) | 1 | letters: typeset | Alfred E. Neuman |
| 8 | Lame Attempts By TV to Explain the 2008 Presidential Vote | comic story | 2 | script: Barry Liebmann; pencils: Ward Sutton; inks: Ward Sutton | Anderson Cooper; Pat Buchanan; Wolf Blitzer; Sean Hannity; James Carvell; Chris Matthews; Tom Brokaw; Chris Matthews |
| 9 | A MAD Look at Snow | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Luth | |
| 11 | MAD's 12 Surefire Tips for Stand-Up Comics | comic story | 3 | script: Jeff Kruse; pencils: Rick Tulka; inks: Rick Tulka; colors: Ryan Flanders | Chad Gorpley |
| 12 | Buy This Stuff Today! | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | Alfred E. Neuman; George Bush; Black Spy; White Spy |
| 13 | MAD's Sucky Twilight Outtakes | comic story | 2 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | |
| 14 | The 2009 Al Jaffee Calendar! | illustration | 2 | pencils: Al Jaffee; inks: Al Jaffee | Alfred E. Neuman; Al Jaffee |
| 15 | An Important Message from MAD's Director of Business & Development | promo (ad from the publisher) | 1 | script: Jeffrey Lozenge | Jeffrey Lozenge |
| 16 | MAD Exposes Who's Thinking What at the Obama Inauguration | comic story | 3 | script: Desmond Devlin, Jacob Lambert, Frank Santopadre, Jeff Kruse, Dennis Snee; pencils: Tom Richmond; inks: Tom Richmond | Bill Clinton; Hillary Clinton; Joe Biden; Barack Obama; John Roberts; Michelle Obama; George Bush; Dick Cheney; Jesse Jackson; Oprah Winfrey; John Kerry; Spider-Man; Paris Hilton; Tiger Woods; John McCain; Cindy McCain; Rush Limbaugh; Sarah Palin; Franklin Delano Roosevelt (ghost); Tina Fey; Dan Rat |
| 17 | Spy vs. Spy | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | Black Spy; White Spy |
| 18 | When Adults Say... Remind Them... | comic story | 2 | script: Jacob Lambert; pencils: Peter Bagge; inks: Peter Bagge | |
| 19 | The MAD World of... Pets | comic story | 3 | script: Stan Sinberg; pencils: Marc Hempel; inks: Marc Hempel | |
| 20 | Monroe and... the Plane Trip | comic story | 4 | script: Anthony Barbieri; pencils: Tom Fowler; inks: Tom Fowler; colors: Carl Peterson | Monroe; Monroe's father; Monroe's mother; Mr. Bines; Walter; Jolinda; Chetly; federal Air Marshall |
| 21 | What the Heck Is the Difference? | activity | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson; colors: Mark Fredrickson | Alfred E. Neuman |
| 22 | MAD's All-Inclusive Do-It-Yourself Celebrity Scandal Blog Posting | comic story | 2 | script: Frank Jacobs, B. Fibbers; pencils: Mort Drucker; inks: Mort Drucker | Amy Winehouse; GEICO caveman; O. J. Simpson; Larry King; John Edwards; Ed McMahon; Joe Biden |
| 23 | Tell-Tale Signs That You've Got a Really Bad Psychic | comic story | 2 | script: Teresa Burns Parkhurst; pencils: Teresa Burns Parkhurst; inks: Teresa Burns Parkhurst; letters: Teresa Burns Parkhurst | |
| 24 | The First 100 Minutes of the Obama Presidency | text story | 2 | script: Frank Santopadre, B. Fibbers; pencils: Drew Friedman; inks: Drew Friedman | Barack Obama; George Bush; Dick Cheney; Michelle Obama; Ruth Bader-Ginsberg; Oprah Winfrey; Rahm Emanuel; Joe The Plumber; Hillary Clinton; John McCain |
| 26 | What Transition of Power Are Many Americans Still Feeling Uneasy About? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | Jay Leno; Conan O'Brien |
| 27 | Drawn-Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |