| 0 | Why So Stupid? | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson | Alfred E. Neuman [as The Joker] |
| 2 | Departments | table of contents | 1 | pencils: various; inks: various; letters: typeset | Alfred E. Neuman; Sarah Palin; Jesse Jackson; George Bush; Dick Cheney; Brett Favre; Gene Simmons; Barack Obama; Rev. Jeremiah Wright |
| 3 | Random Samplings of Reader Mail | letters page | 2.5 | script: John Ficarra, Shepard Fairey; pencils: Richard Thomas, Nadina Simon, Michael Clark; inks: Richard Thomas, Nadina Simon, Michael Clark; colors: Richard Thomas, Nadina Simon, Michael Clark | Barack Obama; Loie Plautz; Joe Biden; Rune Kisch; Todd Palin; Shepard Fairey; Black Spy; White Spy; Alfred E. Neuman |
| 6 | Statement of Ownership | statement of ownership | 0.17 | script: Paul Levitz | |
| 7 | - | credits, title page | 0.33 | letters: typeset | |
| 9 | The Fundalini Pages | comic story | 3 | script: various; pencils: various; inks: various; letters: typeset | Joe Bitterman; Jessica Alba |
| 10 | The MAD 20 | comic story | 24 | script: Desmond Devlin, Jacob Lambert, John Caldwell, Nate Fakes, Frank Santopadre, Scott Maiko; pencils: Scott Bricher, Irving Schild, Charles Akins, Teresa Burns Parkhurst, Hermann Mejía, Mark Stutzman; inks: Scott Bricher, Irving Schild, Charles Akins, Teresa Burns Parkhurst, Hermann Mejía, Mark Stutzman; colors: Scott Bricher, Irving Schild, Charles Akins, Teresa Burns Parkhurst, Hermann Mejía, Mark Stutzman; letters: Gary Hallgren | Sarah Palin; Todd Palin; Joe (the plumber); O. J. Simpson; Hillary Clinton; Billy Ray Cyrus; Miley Cyrus; Britney Spears; Sharon Stone; Dina Lohan; John McCain; John Hagee; Ben Bernacke; Barney Frank; Nancy Pelosi; Dick Cheney; Henry Paulson; Wesley Snipes; Richard Hatch; Amy Winehouse; Barbie; Bara |
| 15 | This Holiday It's Better To Give Than To Receive... | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | Alfred E. Neuman; George Bush; Black Spy; White Spy |
| 16 | Signs You'll Grow Up To Be A Degenerate Gambler | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell; letters: John Caldwell | |
| 17 | Sergio Aragonès Presents A Mad Look at Hard Times | comic story | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: David Rodriguez of Wildstorm FX | |
| 18 | Spy Vs. Spy | comic story | 1 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | Black Spy; White Spy |
| 19 | It's A Good Brand Name...And A Bad Brand Name... | comic story | 2 | script: Jeff Kruse; pencils: Paul Coker; inks: Paul Coker | Michael Vick ?; Popeye |
| 21 | What Important Inhabitant From The North Was In Over Their Head This Year? | activity | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | Sarah Palin; Katie Couric; Charlie Gibson |
| 22 | Drawn-Out Dramas | comic story | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |