| 0 | 50 Worst Things About Advertising | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson | Alfred E. Neuman |
| 2 | Departments | table of contents | 1 | pencils: various; inks: various; letters: typeset | Alfred E. Neuman; Mac guy; Anthony Soprano; Remy |
| 3 | Random Samplings of Reader Mail | letters page | 2.17 | script: John Ficarra | Alfred E. Neuman |
| 5 | - | credits, title page | 0.33 | letters: typeset | |
| 7 | The Fundalini Pages | comic story | 3 | script: various; pencils: various; inks: various; letters: typeset | |
| 9 | MAD's 50 Worst Things About Advertising | comic story | 8 | script: Jeff Kruse, Scott Maiko; pencils: Drew Friedman, Sam Sisco, Tom Bunk, Scott Bricher, Tim Hamilton, Timothy Shamey; inks: Drew Friedman, Sam Sisco, Tom Bunk, Scott Bricher, Tim Hamilton, Timothy Shamey | Mac guy; PC Guy; Matthew Lesko; Oscar Meyer Weinermobile; Chef Boyardee; Jack Bauer; Geico Gecko; Geico cavemen; George Zimmer; Mark McGuire; Black Spy; White Spy |
| 10 | A MAD Look At Ratatouille | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | Remy; Linguini; Skinner |
| 11 | A Collection of Significantly Stupid Strategies for Battling Skyrocketing Gas Prices | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | Walter G. Phurg; Victor Parcheesi; Roy Pastine; Vertin Smidge; Harlan Pilkow; Art Mousseau; Herb Wickam; Hugh Schoonhover; Ted Pondillo; Roy Kaluta |
| 13 | Spy Vs. Spy | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | Black Spy; White Spy |
| 15 | The Strip Club | comic story | 4 | script: Christopher Baldwin, Keith Knight, Ted Rall, Joey Alison Sayers; pencils: Christopher Baldwin, Keith Knight, Ted Rall, Joey Alison Sayers; inks: Christopher Baldwin, Keith Knight, Ted Rall, Joey Alison Sayers; letters: Christopher Baldwin, Keith Knight, Ted Rall, Joey Alison Sayers | George Washington |
| 16 | Monroe and...The Summer Jobs Part 2 | comic story | 4 | script: Anthony Barbieri; pencils: Tom Fowler; inks: Tom Fowler; colors: Ryan Flanders | Monroe; Chompers; Mr. August; rancher; Monroe's father; Mrs. Atkins; Bog Box supervisor; Bucky; Dylan |
| 17 | George W. Bush's Colonoscopy Results | comic story | 1 | script: Al Jaffee; pencils: Hermann Mejía; inks: Hermann Mejía | Donald Rumsfeld; Karl Rove; Mr. Brown; Condoleezza Rice; 'Scotter' Libby; Jack Abramoff; Dick Cheney; Ms. Miers; Alberto Gonzales |
| 18 | Questions We'd Love To See The Media Ask Presidential Candidates | comic story | 2 | script: Jeff Kruse; pencils: Mort Drucker; inks: Mort Drucker | Hillary Clinton, Barack Obama First |
| 19 | MAD's Better, Stronger, Faster Outtakes from Bionic Woman | comic story | 2 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | |
| 20 | A Truly Explosive Sequel! | promo (ad from the publisher) | 1 | letters: typeset | Black Spy; White Spy |
| 21 | America's Next Top Mobster | comic story | 4 | script: Desmond Devlin; pencils: Tom Richmond; inks: Tom Richmond | Anthony Soprano; Sil; Vinnie; Roger; Hohiro Todeki; Enzo; Paulie; Christopher; Bobby Bacala; Phil Keoghan; Jeff Probst; Flavor Flav; Janice; Uncle Junior |
| 22 | What The Heck Is The Difference? | activity | 1 | pencils: Norman Mingo; inks: Norman Mingo | Frankenstein's monster, Alfred E. Neuman |
| 24 | What Hotly Debated Issue Has Americans Split Right Down The Middle? | activity | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 25 | Drawn-Out Dramas | comic story | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |