| 0 | Shrek! (Yecch!) | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson; colors: Mark Fredrickson | Alfred E. Neuman |
| 1 | Departments | table of contents | 1 | pencils: various; inks: various; colors: various; letters: typeset | |
| 2 | - | letters page | 3 | pencils: various; inks: various; colors: various; letters: typeset | |
| 3 | The Fundalini Pages | comic story | 3 | script: Desmond Devlin, Jeff Kruse, Mike Snider, Garth Gerhart; pencils: Paul Coker, Charles Akins, Kevin Pope, Scott Bricher, Gary Hallgren, Irving Schild; inks: Paul Coker, Charles Akins, Kevin Pope, Scott Bricher, Gary Hallgren, Irving Schild; colors: Scott Bricher, Irving Schild, Evan Dorkin, Garth Gerhart | |
| 4 | The OD | comic story | 6 | script: Dennis Snee; pencils: Tom Richmond; inks: Tom Richmond | Peter Gallagher [as Dandy Crowin']; Kelly Rowan [as Kissin' Crowin']; Adam Brody [as Seethe Crowin']; Benjamin McKenzie [as Riot Deadwood]; Mischa Barton [as Mimosa Stupor]; Melinda Clarke [as Jewelry Stupor]; Tate Donovan [as Jittery Stupor]; Chris Carmack [as Galoot]; Rachel Bilson [as Simmer]; Ba |
| 5 | Yao Ming's Chinese-English Phrasebook | comic story | 2 | script: Jonathan Bresman, Scott Sonneborn; pencils: Mort Drucker; inks: Mort Drucker | |
| 6 | Mad's Monstrously Ogre-Rated Shrek 2 Outtakes | photo story | 2 | script: Mike Snider; pencils: Mike Snider; inks: Mike Snider; colors: Mike Snider | |
| 7 | A Mad Look at Braces | comic story | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 8 | Our Letter on Behalf of Martha Stewart | text story | 1 | script: Dave Croatto | |
| 9 | If Corporate 'Mission Statements' Told the Truth | comic story | 3 | script: Jeff Kruse; pencils: Rick Tulka; inks: Rick Tulka | |
| 10 | Star Shrek | comic story | 3 | script: Desmond Devlin; pencils: Hermann Mejía; inks: Hermann Mejía | William Shatner [as Captain James T. Kirk]; Shrek; Donkey; James Doohan [as Montgomery Scott]; Leonard Nimoy [as Spock]; Jack; Jill; Nichelle Nichols [as Lieutenant Uhura]; George Takei [as Mr. Sulu]; The Three Little Pigs; Princess Fiona; Walter Koenig [as Pavel Chekov]; Puss in Boots; Gingy; The T |
| 11 | Monroe and... the Zoo | comic story | 4 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray; letters: Bill Wray | |
| 12 | Mad Ranks the Top Celebrity Prisons | comic story | 2 | pencils: Liz Lomax; inks: Liz Lomax; colors: Liz Lomax | |
| 13 | Tell-Tale Signs Your Parents Have Hired You the Wrong Tutor | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 14 | The Prize Is Slight! | comic story | 5 | script: Dick DeBartolo; pencils: Tom Bunk; inks: Tom Bunk | |
| 15 | Similarities Between the Middle East and the U.S.A. | comic story | 1 | script: Jacob Lambert; pencils: Nathan Fox; inks: Nathan Fox | |
| 16 | Harry Potter and the Outtakes of Azkaban | photo story | 2 | script: Greg Leitman | |
| 17 | Spy vs Spy | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper; colors: Peter Kuper | The Black Spy, The White Spy |
| 18 | There Are Just Some Things You Shouldn't Give the Homeless | comic story | 1 | script: Teresa Burns Parkhurst; pencils: Teresa Burns Parkhurst; inks: Teresa Burns Parkhurst | |
| 19 | Which Celebrity Do Americans Most Want to See Convicted? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |