| 0 | What-Me Barry? | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson | |
| 1 | An Open Letter to Mad Magazine Readers | text story | 1 | script: Bud Selig; letters: typeset | |
| 2 | The Fundalini Pages | comic story | 3 | | |
| 3 | Mission: Implausible III | comic story | 5 | script: Arnie Kogen; pencils: Hermann Mejía; inks: Hermann Mejía | |
| 4 | Barry at the Bat | comic story | 3 | script: Frank Jacobs; pencils: Sam Sisco; inks: Sam Sisco | |
| 5 | Planet Tad!!!!! [August 15, 2006 11:04 AM-August 29, 2006 08:15 PM] | text story | 2 | script: Tim Carvell | |
| 6 | MAD's Exclusive Outtakes from Britney's Dateline NBC Interview! | photo story | 3 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | |
| 7 | A Mad Look at X the Last Stand | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Luth | |
| 8 | Classy Ways to Celebrate Barry Bonds' Historic Season | comic story | 2 | script: Jacob Lambert; pencils: Paul Coker; inks: Paul Coker | |
| 9 | Malicious Seeing-Eye Dogs | comic story | 2 | script: Tom Cheney; pencils: Tom Cheney; inks: Tom Cheney | |
| 10 | The Da Vinci Coma | comic story | 4 | script: Dick DeBartolo; pencils: Mort Drucker; inks: Mort Drucker | Tom Hanks [as Roving Languish]; Audrey Tautou [as Sofa]; Pogo (cameo); Mona Lisa (cameo); Jean Reno [as Bozo Farce]; Alfred Molina [as Bishop Angry-Rosa]; Paul Bettany [as Styleless]; Ian McKellen [as Sir Leaking Teabag] |
| 11 | Little Leaguers on Steroids Trading Cards | comic story | 2 | script: Frank Santopadre; pencils: Mick Coulas, Jack Syracuse; inks: Mick Coulas, Jack Syracuse | Ricky Wallechinsky; Jeremy Klopenstein; Damien Floyd; Tony Chavez |
| 12 | - | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | |
| 13 | What if Carnival Workers Were Major Players in Politics? | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 14 | Mad Celebrates 25 Years of MTV | comic story | 5 | script: Desmond Devlin; pencils: Drew Friedman; inks: Drew Friedman | |
| 15 | Where Is It Most Important to Stop the Influx of Unskilled and Unsavory Workers? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |