| 0 | We Salute Family Guy TV's Most Original Animated Series! | cover | 1 | letters: typeset | |
| 1 | The Fundalini Pages | comic story | 3 | letters: John Caldwell | Uncle Sam; Lindsey Lohan; Mrs. Thelma Tinkle; Abner Squattington; T. M. Buttonneck; Dr. Sal Fung; Veranda Puddle |
| 2 | Selected Scenes from Trading Spouses: Special Animated Edition | comic story | 3 | script: Charlie Kadau; pencils: Gary Hallgren; inks: Gary Hallgren | Homer Simpson; Bart Simpson; Lisa Simpson; Maggie Simpson; Snowball II; Lois Griffin; Marge Simpson; Meg Griffin; Chris Griffin; Peter Griffin; Stewie Griffin; Brian Griffin; Debra Winger [as Paula Pokrifki] (cameo); Barbra Streisand [as Anshel] (cameo); Glenn Quagmire |
| 3 | Planet TAD!!!!! [September 13, 3:08 PM- September 22, 07:47 PM] | text story | 2 | script: Tim Carvell; pencils: Brian Durniak; inks: Brian Durniak | Tad (introduction) |
| 4 | Little Green Army Men of Today's Army | photo story | 2 | script: Darren Johnson; pencils: Irving Schild; inks: Irving Schild | |
| 5 | 7 Periods Closer To Death | comic story | 1 | script: Ted Rall; pencils: Ted Rall; inks: Ted Rall | |
| 6 | A Day in the Life of Adam Sandler | comic story | 2 | script: Scott Maiko; pencils: Drew Friedman; inks: Drew Friedman | Adam Sandler; Rob Schneider |
| 7 | A Mad Look at School Security | comic story | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 8 | Monroe and… The Hospital Stay | comic story | 3 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray | |
| 9 | Mad's Exclusive Backstage Tour of the Family Guy | comic story | 3 | script: Dave Richards; pencils: Tom Richmond; inks: Tom Richmond; colors: Tom Richmond | Nemo; Hank Hill; Brian Griffin; Scooby-Doo; Matt Stone; Trey Parker; Homer Simpson; Snoopy; Lisa Simpson; Alex Borstein; Seth Green; Mila Kunis; Roger; Steve Smith; Bobby Hill; Bart Simpson; Seth MacFarlane; Adam West; Bender; Rupert Murdoch; Beavis; Butthead; Stan Smith; Stewie Griffin; Peter Griff |
| 10 | John Caldwell's If There Were No Such Things as Video Games | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell; letters: John Caldwell | |
| 11 | Mad's Fall TV Preview 2005 | comic story | 4 | script: Scott Maiko; pencils: Hermann Mejía; inks: Hermann Mejía | |
| 12 | Spy vs. Spy | comic story | 1 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | |
| 13 | Go Fetch! | text article | 3 | pencils: Tom Nick Cocotos; inks: Tom Nick Cocotos | |
| 14 | Bore of the Worlds | comic story | 4 | script: Arnie Kogen; pencils: Mort Drucker; inks: Mort Drucker | Justin Chatwin [as Rubble]; Linus Van Pelt (cameo); Tim Robbins [as Harlan Wackabee]; Steven Spielberg; Dakota Fanning {as Rattle]; E.T. |
| 15 | What Threat to Our American Way of Life Needs to Be Constantly Checked? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |