| 0 | Our 400th Moronic Issue! | cover | 1 | pencils: Robert Silvers; inks: Robert Silvers | |
| 1 | Celebrity Palm Ads We’d Like to See: Forcefully Palm | photo story | 1 | script: Arie Kaplan; pencils: Irving Schild; inks: Irving Schild | |
| 2 | The Untold History of Mad Magazine | comic story | 10 | script: Desmond Devlin; pencils: Scott Bricher, Drew Friedman, Al Jaffee, Sergio Aragonés, Paul Coker, Angelo Torres; inks: Scott Bricher, Drew Friedman, Al Jaffee, Sergio Aragonés, Paul Coker, Angelo Torres | |
| 3 | A Mad Look at TV | comic story | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 4 | Monroe and… a Day with Dad | comic story | 4 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray | |
| 5 | Mad 400 Pullout Poster | illustration | 2 | pencils: Robert Silvers; inks: Robert Silvers | |
| 6 | You’re Probably Not Heading to College if… | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 7 | “Instant Ready Keyboard” Commands That Tell it Like It Is | comic story | 1 | script: Dick DeBartolo; pencils: Tom Bunk; inks: Tom Bunk | |
| 8 | What Drives You Mad? | comic story | 4 | pencils: John Kascht; inks: John Kascht | Jimmy Kimmel; Adam Carolla; Winona Ryder; Tom Wolfe; Bob Guccione, Jr.; Greg Grunberg; Senator Frank Lautenberg; Senator Wayne Allard; Senator Susan Collins; Representative Barney Frank; Kevin Smith; Mort Walker; Fred Schneider; Jason Alexander |
| 9 | The Lighter Side of... | comic story | 4 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | Roger Kaputnik |
| 10 | Celebrity Palm Ads We'd Like to See: Sexually Palm | photo story | 1 | script: Arie Kaplan; pencils: Irving Schild; inks: Irving Schild | |
| 11 | - | comic story | 2 | script: Dave Croatto; pencils: Peter Kuper; inks: Peter Kuper | Black Spy; White Spy |
| 12 | More Contractual Obligations We’d Like to See Some Celebrities Agree to | comic story | 3 | script: Russ Cooper; pencils: Mort Drucker; inks: Mort Drucker | |
| 13 | Goodnight Room | comic story | 5 | script: Desmond Devlin; pencils: Jack Syracuse; inks: Jack Syracuse; colors: Digital Chameleon | |
| 14 | Mad’s Celebrity Cause-of-Death Betting Odds | comic story | 1 | script: Mike Snider; pencils: Jon Weiman; inks: Jon Weiman | Vince McMahon |
| 15 | What Magazine is Celebrating a Milestone With Much Fanfare? | activity | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 16 | Celebrity Palm Ads We’d Like to See: Sickly Palm | photo story | 1 | script: Arie Kaplan; pencils: Irving Schild; inks: Irving Schild | |