| 0 | Alfred E. Neuman | cover | 1 | pencils: Mort Drucker; inks: Mort Drucker; colors: Mort Drucker | Robin Williams [as Popeye]; Shelley Duvall [as Olive Oyl]; Alfred E. Neuman [as Swee'pea] |
| 1 | Mad Super Special Winter 1981 | promo (ad from the publisher) | 1 | | Alfred E. Neuman |
| 2 | Table of Contents | table of contents | 1 | pencils: various; inks: various; letters: typeset | |
| 3 | Flopeye | comic story | 7 | script: Stan Hart; pencils: Mort Drucker; inks: Mort Drucker | Popeye (cameo); Robin Williams [as Flopeye]; Shelley Duvall [as Olives Oil]; Paul Dooley [as Wimpy]; Paul L. Smith [as Bruto]; Ray Walston [as Pappy]; Charlie Brown (cameo); Lucy Van Pelt (cameo); Snoopy (cameo); Swee'tea |
| 4 | Don Martin Dept. Part I: One Blazing Hot Day on the Desert | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin; letters: Don Martin | |
| 5 | A Mad Look at Some... Celebrities Diapers | comic story | 2 | script: Paul Peter Porges; pencils: Bob Clarke; inks: Bob Clarke | Attila the Hun; Hare Krishna; Jesse James; Pythagoras; Harry Houdini; Mickey Mouse; Muhammad Ali; Napoleon; The Grand Dragon of the Ku Klux Klan; Yasir Arafat; Lady Godiva; Steve Martin; Arnold Schwarzeneger; Kiss |
| 6 | If They Can Put a Man on the Moon, Then Why Can't They... | comic story | 3 | script: John Ficarra; pencils: Jack Davis; inks: Jack Davis | |
| 7 | Mad's Airline President of the Year | comic story | 4 | script: Frank Jacobs; pencils: George Woodbridge; inks: George Woodbridge | O.G. Simpleton; Mr. Quincy Widebody; Jasper Wiltfang |
| 8 | Mad's Really Relevant Book of Lists | comic story | 3 | script: Frank Jacobs | |
| 9 | Publically Prohibited Bad Habits of the Future | comic story | 2 | script: Dennis Snee; pencils: Jack Rickard; inks: Jack Rickard | |
| 10 | Letters Dept. | letters page | 1 | pencils: ? (photos); ?; inks: ? (photos); ?; letters: typeset | Anthony Perkins (photo); Dick Clark (photo); Cathy Gaines Misfud (daughter of William Gaines; wedding photo); Steve Misfud (wedding photo) |
| 11 | Altered States Flip Cover | illustration | 1 | pencils: Jack Rickard; inks: Jack Rickard; colors: Jack Rickard | Alfred E. Neuman |
| 12 | What Ancient Slow-Moving Creature Is Threatened with Extinction? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 13 | Table of Contents | table of contents | 1 | pencils: various; inks: various; letters: typeset | |
| 14 | Assaulted State | comic story | 6 | script: Dick DeBartolo; pencils: Angelo Torres; inks: Angelo Torres | Bob Balaban [as Artwerp]; William Hurt [as Oddie]; Charles Haid [as Perish]; George Gaynes [as Dr. Carmella]; Blair Brown [as Enema] |
| 15 | Real Life Madness | comic story | 3 | script: Lou Silverstone; pencils: Harry North; inks: Harry North | |
| 16 | Don Martin Dept. Part I: One Blazing Hot Day on the Beach | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 17 | William Shakespeare... Social Critic | photo story | 2 | script: Henry Clark; pencils: UPI; inks: UPI | William Shakespeare; Kiss; Rolling Stones; Mork & Mindy; Alfred E. Neuman; Barbra Streisand |
| 18 | The Lighter Side of... | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 19 | Spy vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías; letters: Antonio Prohías | Black Spy; White Spy |
| 20 | Mad's Career-Oriented Mother Goose | comic story | 3 | script: Frank Jacobs; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 21 | Don Martin Dept. Part II: One Blazing Hot Day on Main Street | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin; letters: Don Martin | |
| 22 | Drawn-Out Dramas | comic story | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; letters: Sergio Aragonés | |