| 0 | Mad No Longer Contains Cyclamate or M.S.G. | cover | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |
| 1 | - | letters page | 0.5 | script: Jerry De Fuccio | |
| 2 | - | statement of ownership | 0.2 | script: William M. Gaines | |
| 3 | Why Not Have the Next Issue Sent Directly to Your Home? | promo (ad from the publisher) | 0.67 | script: Nick Meglin; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 4 | True Fat | comic story | 6 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | John Wayne [as Booster Claghorn]; Kim Darby [as Brattie Ross]; Glen Campbell [as LaBeefy]; Jeff Corey [as Tom Shamey]; Strother Martin [as The Colonel] |
| 5 | The Facts of Life (& Death) | comic story | 2 | script: Ronnie Nathan; pencils: Jack Davis; inks: Jack Davis | |
| 6 | If TV Shows Were Actually Like Their Capsule Descriptions | comic story | 3 | script: Earle Doud; pencils: Angelo Torres; inks: Angelo Torres | Dean Martin; George Hamilton; Pat Paulsen; Nancy Sinatra; Elaine "Spanky" McFarlane; Marlin Perkins; Jim Fowler; Walter Cronkite; David Susskind; Gore Vidal; Norman Mailer; Lawrence Welk; Kyle Rote |
| 7 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 8 | During a Summer Shower | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 9 | Mad's Do-It-Yourself Modern Movie Ads | comic story | 2 | script: Sy Reit; pencils: Bob Clarke; inks: Bob Clarke | |
| 10 | The Lighter Side of Family Gatherings | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 11 | Dreams That Went Up in Smoke | photo story | 1 | script: Max Brandel | Ronald Reagan |
| 12 | What Is a Born Winner? | text story | 2 | script: Al Jaffee; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 13 | Mad's Lifetime Chart of Attitudes and Behaviors | comic story | 4 | script: Frank Jacobs; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 14 | Future Instant Predictions | comic story | 2 | script: William Garvin; pencils: Jack Rickard; inks: Jack Rickard | |
| 15 | Spy vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 16 | A Mad Look at Antiques of the Future | photo story | 3 | script: Sy Reit; pencils: Irving Schild; inks: Irving Schild | |
| 17 | A Mad Peek Behind the Scenes at the U. S. Congress | comic story | 2 | script: Lou Silverstone; pencils: Bob Clarke; inks: Bob Clarke | |
| 18 | A Mad Look at Celebrities in Real-Life Situations | comic story | 3 | script: Larry Siegel; pencils: John Johns; inks: John Johns | Aristotle Onassis; Jacqueline Kennedy-Onassis; John Lennon; Yoko Ono; Sammy Davis Jr.; Hugh Hefner; Frank Sinatra; Richard Nixon; Pat Nixon; Spiro Agnew |
| 19 | Spy vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 20 | Joe Namath's Wallet | comic story | 2 | script: Arnie Kogen | |
| 21 | One Day in the Mountains | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 22 | Mad Green Paper: The State of Our Suburbs | comic story | 4 | script: Stan Hart; pencils: George Woodbridge; inks: George Woodbridge | |
| 23 | What Is One Special Benefit Derived From Modern Rock Music By Some of Its Fans? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 24 | A Valentine to All Our Mad Readers | illustration | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |