| 0 | - | cover | 1 | pencils: Neal Adams; inks: Neal Adams; colors: Matt Milla | |
| 1 | - | credits, title page | 1 | pencils: Sal Buscema; inks: Jim Mooney | |
| 2 | - | cover reprint (on interior page) | 1 | pencils: Neal Adams; inks: Neal Adams; letters: Sam Rosen | |
| 3 | The Day of the Defenders! | comic story | 19 | script: Roy Thomas; pencils: Ross Andru; inks: Bill Everett; letters: Sam Rosen | Defenders [Hulk; Dr. Strange; Namor, the Sub-Mariner] (introduction, origin); Wong; Yandroth (villain, dies); Omegatron (introduction); Silver Surfer |
| 4 | The Return! | comic story | 10 | script: Roy Thomas; pencils: Don Heck; inks: Frank Giacoia; letters: Sam Rosen | Dr. Strange [Stephen Strange, also as Stephen Sanders]; Wong; Ancient One; Baron Mordo (villain) |
| 5 | - | cover reprint (on interior page) | 1 | script: Roy Thomas; pencils: John Buscema, John Romita; inks: Frank Giacoia | |
| 6 | Nightmare on Bald Mountain! | comic story | 28 | script: Roy Thomas; pencils: Ross Andru; inks: Sal Buscema; letters: Sam Rosen | Defenders [Hulk [Bruce Banner]; Namor, the Sub-Mariner; Dr. Strange]; Dormammu; Wong; Clea; Roy Thomas; Jean Thomas; Tom Fagan; Dormammu cultists (introduction, die) |
| 7 | - | cover reprint (on interior page) | 1 | script: Roy Thomas; pencils: Gil Kane; inks: Ralph Reese | |
| 8 | A Titan Walks Among Us! | comic story | 23 | script: Roy Thomas; pencils: Ross Andru; inks: Bill Everett; letters: Art Simek | Defenders [Dr. Strange; Namor, the Sub-Mariner; Hulk [Bruce Banner]]; Xemnu the Titan; Jim Wilson; Thunderbolt Ross; Colonel Calvin Beame (dies); Colonel Richmond Wagner |
| 9 | - | promo (ad from the publisher) | 1 | pencils: Jack Kirby, Neal Adams; inks: Vince Colletta, Neal Adams | |