| 0 | - | cover | 1 | pencils: Reilly Brown; inks: Reilly Brown; colors: Jim Charalampidis | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 1 | Title Page and Credits | credits, title page | 3 | pencils: Reilly Brown; inks: Reilly Brown, Jay Leisten; colors: Jim Charalampidis | |
| 2 | - | cover reprint (on interior page) | 1 | pencils: Reilly Brown; inks: Reilly Brown; colors: Jim Charalampidis | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Rob Liefeld; inks: Rob Liefeld; colors: Romulo Fajardo | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 4 | Split Second Chapter One: Not Apollo Creed | comic story | 14 | script: Fabian Nicieza, Reilly Brown; pencils: Reilly Brown; inks: Reilly Brown, Jay Leisten; colors: Jim Charalampidis; letters: VC's Joe Sabino | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 5 | Split Second Chapter Two: Return of the Bosom Buddies | comic story | 16 | script: Fabian Nicieza, Reilly Brown; pencils: Reilly Brown; inks: Reilly Brown, Jay Leisten; colors: Jim Charalampidis; letters: VC's Joe Sabino | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Reilly Brown; inks: Reilly Brown; colors: Jim Charalampidis | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 7 | Split Second Chapter Three: Santayana Was Right | comic story | 15 | script: Fabian Nicieza, Reilly Brown; pencils: Reilly Brown; inks: Reilly Brown, Jay Leisten; colors: Jim Charalampidis; letters: VC's Joe Sabino | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 8 | Split Second Chapter Four: The Future Isn't What It Used to Be! | comic story | 15 | script: Fabian Nicieza, Reilly Brown; pencils: Reilly Brown; inks: Reilly Brown, Jay Leisten; colors: Jim Charalampidis; letters: VC's Joe Sabino | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 9 | - | cover reprint (on interior page) | 1 | pencils: Reilly Brown; inks: Reilly Brown; colors: Jim Charalampidis | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 10 | Split Second Chapter Five | comic story | 16 | script: Fabian Nicieza, Reilly Brown; pencils: Reilly Brown; inks: Reilly Brown, Jay Leisten; colors: Jim Charalampidis; letters: VC's Joe Sabino | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 11 | Split Second Chapter Six | comic story | 14 | script: Fabian Nicieza, Reilly Brown; pencils: Reilly Brown; inks: Reilly Brown, Jay Leisten; colors: Jim Charalampidis; letters: VC's Joe Sabino | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 12 | - | cover reprint (on interior page) | 1 | pencils: Kris Anka; inks: Kris Anka; colors: Kris Anka | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 13 | - | cover reprint (on interior page) | 1 | pencils: Dan Panosian; inks: Dan Panosian; colors: Dan Panosian | Cable, Deadpool, Nathan Summers, Wade Wilson |
| 14 | Amazing Spider-Man (1999) #620 Deadpool Variant | cover reprint (on interior page) | 1 | pencils: Pasqual Ferry; inks: Pasqual Ferry; colors: Fabio D'Auria | Deadpool, J. Jonah Jameson, Harry Osborn, Peter Parker, Spider-Man, Mary Jane Watson, Wade Wilson |
| 15 | Amazing Spider-Man (2014) #7 Deadpool 75th Anniversary Variant | cover reprint (on interior page) | 1 | pencils: Michael Golden; inks: Michael Golden; colors: Michael Golden | Deadpool, Peter Parker, Spider-Man, Wade Wilson |
| 16 | Daredevil #505 Deadpool Variant | cover reprint (on interior page) | 1 | pencils: Max Fiumara; inks: Max Fiumara; colors: Max Fiumara | Daredevil, Deadpool, Matt Murdock, Wade Wilson |
| 17 | Deadpool (2012) #1 Variant | cover reprint (on interior page) | 1 | pencils: Skottie Young; inks: Skottie Young; colors: Skottie Young | Deadpool [Wade Wilson] |
| 18 | Deadpool (2012) #1 Design Variant | cover reprint (on interior page) | 1 | pencils: Tony Moore; inks: Tony Moore; colors: Tony Moore | Deadpool, Wade Wilson |
| 19 | Hulk (2014) #7 Deadpool 75th Anniversary Variant | cover reprint (on interior page) | 1 | pencils: David Marquez; inks: David Marquez; colors: Edgar Delgado | Bruce Banner, Deadpool, Hulk, Logan, Wade Wilson, Wolverine |
| 20 | Secret Wars #1 Variant | cover reprint (on interior page) | 1 | pencils: Neal Adams; inks: Neal Adams; colors: Frank Martin | Deadpool, Wade Wilson |
| 21 | Spider-Man 2099 #4 Variant | cover reprint (on interior page) | 1 | pencils: Greg Land; inks: Greg Land; colors: Frank D'Armata | Deadpool, Peter Parker, Spider-Man, Gwen Stacy, Wade Wilson |
| 22 | Uncanny Avengers #1 Deadpool Call Me Maybe Variant | cover reprint (on interior page) | 1 | pencils: Mark Brooks; inks: Mark Brooks; colors: Mark Brooks | Deadpool, Wade Wilson |
| 23 | Uncanny Avengers #25 Deadpool 75th Anniversary Variant | cover reprint (on interior page) | 1 | pencils: Khoi Pham; inks: Khoi Pham; colors: Frank D'Armata | Bruce Banner, Clint Barton, Black Widow, Captain America, Deadpool, Nick Fury Jr., Hawkeye, Hulk, Iron Man, Steve Rogers, Natasha Romanoff, Tony Stark, Thor, Wade Wilson |
| 24 | Wolverine #1 Deadpool Variant | cover reprint (on interior page) | 1 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Christina Strain | Logan, Wolverine |
| 25 | Uncanny X-Men #27 Deadpool 75th Anniversary Variant | cover reprint (on interior page) | 1 | pencils: Mike McKone; inks: Mike McKone; colors: Jason Keith | Angel, Beast, Colossus, Cyclops, Deadpool, Bobby Drake, Iceman, Logan, Hank McCoy, Nightcrawler, Piotr Rasputin, Scott Summers, Kurt Wagner, Wade Wilson |