| 0 | - | cover | 1 | pencils: Jason Pearson; inks: Jason Pearson; colors: Jason Pearson | Deadpool, Peter Parker, Spider-Man, Wade Wilson |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Jason Pearson; inks: Jason Pearson; colors: Jason Pearson | Deadpool, Peter Parker, Spider-Man, Wade Wilson |
| 2 | Whatever a Spider Can, Part 1: Start Spreadin' the News | comic story | 22 | script: Daniel Way; pencils: Carlo Barberi; inks: Juan Vlasco, Sandu Florea; colors: Marte Gracia; letters: Joe Sabino, Virtual Calligraphy | Deadpool, Hit-Monkey First, Peter Parker, Robbie Robertson, Spider-Man, Wade Wilson |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Jason Pearson; inks: Jason Pearson; colors: Jason Pearson | Deadpool, Hit-Monkey First, Peter Parker, Spider-Man, Wade Wilson |
| 4 | Whatever a Spider Can Part 2 of 3 | comic story | 22 | script: Daniel Way; pencils: Carlo Barberi; inks: Sandu Florea; colors: Marte Gracia; letters: Virtual Calligraphy, Joe Sabino | Deadpool, Hit-Monkey First, Peter Parker, Spider-Man, Wade Wilson |
| 5 | - | cover reprint (on interior page) | 1 | pencils: Jason Pearson; inks: Jason Pearson; colors: Jason Pearson | Deadpool, Hit-Monkey First, Peter Parker, Spider-Man, Wade Wilson |
| 6 | Whatever a Spider Can Part 3 of 3 | comic story | 22 | script: Daniel Way; pencils: Carlo Barberi; inks: Sandu Florea; colors: Marte Gracia; letters: Virtual Calligraphy, Joe Sabino | Deadpool, Ben Grimm, Hit-Monkey First, Human Torch, Invisible Woman, Mister Fantastic, Peter Parker, Reed Richards, Spider-Man, Susan Storm Richards, Johnny Storm, The Thing, Wade Wilson |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Jason Pearson; inks: Jason Pearson; colors: Jason Pearson | Deadpool, Wade Wilson |
| 8 | Deadpool #22 Iron Man by Design Variant | cover reprint (on interior page) | 1 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | Iron Man, Tony Stark |
| 9 | Do Idiots Dream of Electric Stupidity? | comic story | 22 | script: Daniel Way; pencils: Tan Eng Huat; inks: Tan Eng Huat; colors: Marte Gracia; letters: Virtual Calligraphy, Joe Sabino | Deadpool, Thor, Wade Wilson |
| 10 | Introducing the World's Greatest Assassin | cover reprint (on interior page) | 1 | pencils: Frank Cho; inks: Frank Cho | Hit-Monkey First |
| 11 | Hit-Monkey #1 Second Printing Variant | cover reprint (on interior page) | 1 | pencils: Frank Cho; inks: Frank Cho | Hit-Monkey First |
| 12 | - | comic story | 22 | script: Daniel Way; pencils: Dalibor Talajić; inks: Dalibor Talajić; colors: Matt Hollingsworth; letters: Jeff Eckleberry | Hit-Monkey First |