| 0 | - | cover | 1 | pencils: Joe Madureira; inks: Joe Madureira; colors: Aron Lusen | Avengers [Spider-Man; Red Hulk; Wolverine; Spider-Woman] |
| 1 | Credits Page | credits, title page | 1 | letters: typeset | |
| 2 | - | cover reprint (on interior page) | 1 | pencils: Joe Madureira; inks: Joe Madureira; colors: Aron Lusen | Avengers [Spider-Man; Red Hulk; Wolverine; Spider-Woman] |
| 3 | - | comic story | 22 | script: Zeb Wells; pencils: Joe Madureira; colors: Ferran Daniel; letters: VC's Joe Caramagna | Harvey Elder, J. Jonah Jameson, Mole Man, Peter Parker, Spider-Man |
| 4 | - | cover reprint (on interior page) | 1 | pencils: Joe Madureira; colors: Ferran Daniel | Peter Parker, Red Hulk, Thaddeus "Thunderbolt" Ross, Spider-Man |
| 5 | - | comic story | 21 | script: Zeb Wells; pencils: Joe Madureira; colors: Ferran Daniel; letters: VC's Joe Caramagna | Harvey Elder, J. Jonah Jameson, Mole Man, Peter Parker, Red Hulk, Thaddeus "Thunderbolt" Ross, Spider-Man |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Joe Madureira; colors: Ferran Daniel | Peter Parker, Spider-Man |
| 7 | - | comic story | 21 | script: Zeb Wells; pencils: Joe Madureira; colors: Ferran Daniel; letters: VC's Joe Caramagna | Jessica Drew, Harvey Elder, Iron Man, J. Jonah Jameson, Mole Man, Peter Parker, Red Hulk, Steve Rogers, Thaddeus "Thunderbolt" Ross, Spider-Man, Spider-Woman, Tony Stark |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Greg Land; inks: Greg Land; colors: Justin Ponsor | Clint Barton, Hawkeye, Peter Parker, Spider-Man |
| 9 | - | credits, title page | 1 | script: Zeb Wells; pencils: Joe Madureira, Greg Land; inks: Joe Madureira, Greg Land; colors: Ferran Daniel, Justin Ponsor | |
| 10 | - | comic story | 20 | script: Zeb Wells; pencils: Greg Land; inks: Jay Leisten; colors: Wil Quintana; letters: VC's Joe Caramagna | Clint Barton, Gregory Bryan First, Hawkeye, Peter Parker, Sidewinder First, Spider-Man |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Leinil Francis Yu; inks: Leinil Francis Yu; colors: Jason Keith | Captain America, Peter Parker, Steve Rogers, Spider-Man |
| 12 | - | recap | 1 | pencils: Joe Madureira, Leinil Francis Yu; inks: Joe Madureira, Leinil Francis Yu; colors: Ferran Daniel | |
| 13 | - | comic story | 20 | script: Zeb Wells; pencils: Leinil Francis Yu; inks: Gerry Alanguilan; colors: Sunny Gho; letters: VC's Joe Caramagna | Avengers [Spider-Man [Peter Parker]; Captain America; Spider-Woman [Jessica Drew]; Hawkeye [Clint Barton]; Wolverine; Red Hulk [Thunderbolt Ross]]; Serpent Society [Copperhead; Anaconda (cameo); Cottonmouth (cameo)]; Adolf Hitler (cameo flashback) |
| 14 | - | cover reprint (on interior page) | 0.5 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Iron Man, Peter Parker, Spider-Man, Tony Stark |
| 15 | - | cover reprint (on interior page) | 0.5 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Edgar Delgado | Captain America, Peter Parker, Steve Rogers, Spider-Man |
| 16 | - | cover reprint (on interior page) | 2 | pencils: Joe Quesada; inks: Danny Miki; colors: Richard Isanove | Peter Parker, Spider-Man |
| 17 | - | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Dexter Vines; colors: Morry Hollowell | Peter Parker, Red Hulk, Thaddeus "Thunderbolt" Ross, Spider-Man |
| 18 | #3 Spider-Man 50th Anniversary Variant | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Anna Marie, Clint Barton, Black Cat, Tandy Bowen, Danielle Cage, Captain America, Cloak, Carlie Cooper, Anya Corazon, Cyclops, Dagger, Carol Danvers, Bobby Drake, Jessica Drew |
| 19 | - | cover reprint (on interior page) | 1 | pencils: Dale Keown; inks: Dale Keown; colors: Peter Steigerwald | Clint Barton, Hawkeye, Peter Parker, Spider-Man |