| 0 | Mastermind Excello; The Great Video; Heartbreak Kid; Blackjack; Monstro; Positron | cover | 1 | pencils: Pete Woods; inks: Pete Woods | Peter Parker, Spider-Man |
| 1 | Table of Contents | table of contents | 1 | letters: typeset | |
| 2 | Mastermind Excello | comic story | 8 | script: Greg Pak; pencils: Takeshi Miyazawa; inks: Takeshi Miyazawa; colors: Christina Strain; letters: Artmonkeys' Dave Lanphear | Mastermind Excello [Amadeus Cho]; Hulk [Bruce Banner]; Agent Sexton |
| 3 | Case #714: Heavy on Action, Light on Plot | comic story | 2 | script: Dan Slott; pencils: Pete Woods; inks: Pete Woods; colors: Brad Anderson; letters: Artmonkeys' Dave Lanphear | G.R.A.M.P.A. [Global Reaction Agency for Mysterious Paranormal Activity; Ace; One-Eyed Jacquie; Grampa] |
| 4 | The Man with X-Ray Eyes | comic story | 8 | script: Daniel Way; pencils: Nick Dragotta; inks: Nick Dragotta; colors: Lee Loughridge; letters: Artmonkeys' Dave Lanphear | The Great Video [Mr. Vance]; Detective Schumer; Detective Blake; Janie; Paul |
| 5 | Case #538: The Winning Hand | comic story | 2 | script: Dan Slott; pencils: Pete Woods; inks: Pete Woods; colors: Brad Anderson; letters: Artmonkeys' Dave Lanphear | G.R.A.M.P.A. [Global Reaction Agency for Mysterious Paranormal Activity; Ace; One-Eyed Jacquie]; VILLAIN: Terminus |
| 6 | Monstro | comic story | 8 | script: Robert Kirkman; pencils: Khary Randolph; inks: John Stanisci; colors: Val Staples; letters: Artmonkeys' Dave Lanphear | Monstro [Frank]; John |
| 7 | Case #803: You Say You Want an Evolution? | comic story | 2 | script: Dan Slott; pencils: Pete Woods; inks: Pete Woods; colors: Brad Anderson; letters: Artmonkeys' Dave Lanphear | G.R.A.M.P.A. [Global Reaction Agency for Mammal/Primate Affairs; Ace; One-Eyed Jacquie; Grampa]; VILLAIN: King Sapien [King Simian] |
| 8 | Heartbreak Kid! | comic story | 8 | script: Roberto Aguirre-Sacasa; pencils: Jeff Parker; inks: Sal Buscema; colors: Lovern Kindzierski; letters: Artmonkeys' Dave Lanphear | Heartbreak Kid [Danny Shepard]; Peter Parker [Spider-Man]; Flash Thompson; Aunt May Parker |
| 9 | Case #999: Happy Ending | comic story | 2 | script: Dan Slott; pencils: Pete Woods; inks: Pete Woods; colors: Brad Anderson; letters: Artmonkeys' Dave Lanphear | G.R.A.M.P.A. [Global Reaction Agency for Mysterious Paranormal Activity; Ace; One-Eyed Jacquie] |
| 10 | Positron | comic story | 8 | script: Sean McKeever; pencils: Kristian Donaldson; inks: Kristian Donaldson; colors: Kristian Donaldson; letters: Artmonkeys' Dave Lanphear; editing: MacKenzie Cadenhead | Positron [Annie]; Jackson Clarke; Annie's father |
| 11 | I Was That Guy in Spider-Man's Armpit! | comic story | 2 | script: Dan Slott; pencils: Patrick Scherberger; inks: Norman Lee; colors: Matt Nelson; letters: Artmonkeys' Dave Lanphear | Spider-Man [Peter Parker]; Steve |
| 12 | Amazing Fantasy | text article | 1 | script: Mark Paniccia | |