| 0 | Cover A | cover | 1 | pencils: John K. Snyder III; inks: John K. Snyder III; colors: Jason Wright | Admiral James T. Kirk; Mr. Spock |
| 1 | Infestation Update | recap | 1 | pencils: John K. Snyder III, Gabriel Rodriguez, Gordon Purcell, Casey Maloney, Gary Erskine; inks: John K. Snyder III, Gabriel Rodriguez, Gary Erskine; colors: Jason Wright, Luis Antonio Delgado | Admiral James T. Kirk; Mr. Spock; Bones [Dr. Leonard McCoy] |
| 2 | - | comic story | 22 | script: Scott Tipton, David Tipton; pencils: Casey Maloney, Gary Erskine; inks: Gary Erskine; colors: Luis Antonio Delgado; letters: Chris Mowry | Admiral James T. Kirk; Mr. Spock; Bones [Dr. Leonard McCoy]; Barnes; Emigh; Padilla |
| 3 | Cover Preview - Star Trek: Infestation #2 | promo (ad from the publisher) | 1 | pencils: Casey Maloney, Gordon Purcell; inks: Casey Maloney, Gordon Purcell; colors: Luis Antonio Delgado | Admiral James T. Kirk; Mr. Spock; Bones [Dr. Leonard McCoy] |
| 4 | Sneak Peak: Tranformers: Infestation #1 | preview (from the publisher) | 2 | script: Dan Abnett, Andy Lanning; pencils: Nick Roche; inks: Nick Roche; colors: Joana Lafuente; letters: Robbie Robbins; editing: Andy Schmidt, Bobby Curnow | Galvatron; Optimus Prime; Bumblebee; Kup; Prowl; Wheeljack; Major Spike Witwicky |
| 5 | Sneak Peak: G.I. Joe: Infestation #1 | preview (from the publisher) | 2 | script: Mike Raicht; pencils: Giovanni Timpano | Baroness |
| 6 | Sneak Peak: Ghostbusters: Infestation #1 | preview (from the publisher) | 2 | script: Erik Burnham; pencils: Kyle Hotz; inks: Kyle Hotz | Dr. Egon Spengler; Winston Zeddemore |
| 7 | Infestation Checklist | promo (ad from the publisher) | 1 | | |