| 0 | - | cover | 1 | pencils: Phil Moy; inks: Phil Moy; colors: Jason Lewis | |
| 1 | - | blank page(s) | 1 | | |
| 2 | The Powerpuff Girls Classics Volume 4 | credits, title page | 1 | letters: typeset | |
| 3 | - | credits, title page | 1 | letters: typeset | |
| 4 | A Fear-y Tale! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Todd Klein | |
| 5 | Bedcrime Story | comic story | 22 | script: Jennifer Moore, Sean Carolan; pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Jenna Garcia; editing: Harvey Richards, Joan Hilty | |
| 6 | The Trouble with Bubbles! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Todd Klein | |
| 7 | The Trouble with Bubbles | comic story | 22 | script: Brett Lewis; pencils: Christopher Cook; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Jenna Garcia, Gustav; editing: Harvey Richards, Joan Hilty | |
| 8 | Bad Vibes! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | |
| 9 | Mojo Dojo | comic story | 10 | script: Jennifer Moore, Sean Carolan; pencils: Stephanie Gladden; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Jenna Garcia; editing: Harvey Richards, Joan Hilty | |
| 10 | Now & Zen | comic story | 12 | script: Ian Boothby, Roger Fredrichs; pencils: Bill Alger; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Jenna Garcia; editing: Harvey Richards, Joan Hilty | |
| 11 | What's Wrong with This Picture? | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Buttercup; Blossom; Bubbles |
| 12 | Bow Jest | comic story | 22 | script: Jennifer Moore, Sean Carolan; pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Jenna Garcia; editing: Harvey Richards, Joan Hilty | Blossom; Buttercup; Bubbles; Professor Utonium; Princess Morbucks; Mojo Jojo; Ms. Keane; Mayor; Sara Bellum; Mitch Mitchelson (cameo) |
| 13 | Liar, Liar, City on Fire! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Todd Klein | |
| 14 | Big Fish Story | comic story | 22 | script: Frank Strom; pencils: Christopher Cook; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Jenna Garcia; editing: Harvey Richards, Joan Hilty | |
| 15 | Powerpuff Polite! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Todd Klein | Buttercup; Bubbles; Blossom; Fuzzy Lumpkins |
| 16 | My Fair Fuzzy | comic story | 12 | script: John Rozum; pencils: Bill Alger; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Jenna Garcia; editing: Harvey Richards, Joan Hilty | Blossom; Buttercup; Bubbles; Fuzzy Lumpkins; Mayor; Sara Bellum; Professor Utonium |
| 17 | Brat Worst | comic story | 10 | script: Trina Robbins; pencils: Ricardo Garcia Fuentes; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Jenna Garcia; editing: Harvey Richards, Joan Hilty | Buttercup; Bubbles; Blossom; Professor Utonium; Mayor; Sara Bellum; Mojo Jojo; Princess Morbucks; Gangreen Gang [Ace; Big Billy; Snake; Grubber; Li'l Arturo] |
| 18 | - | blank page(s) | 1 | | |
| 19 | - | illustration | 1 | letters: typeset | |