| 0 | - | cover | 1 | pencils: Phil Moy; inks: Phil Moy; colors: Jason Lewis | |
| 1 | - | blank page(s) | 1 | | |
| 2 | The Powerpuff Girls Classics Volume 2 | credits, title page | 1 | letters: typeset | |
| 3 | - | credits, title page | 1 | letters: typeset | |
| 4 | - | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Bubbles; Blossom; Buttercup; Mojo Jojo (shadow only) |
| 5 | Holy Molar! | comic story | 22 | script: Jennifer Moore, Sean Carolan; pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Ryan Cline; editing: Harvey Richards, Joan Hilty | Blossom; Buttercup; Bubbles; Mojo Jojo; Professor Utonium; Mayor |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Buttercup; Blossom; Bubbles; Mojo Jojo |
| 7 | Dial "M" for Mojo! | comic story | 22 | script: John Rozum; pencils: Ricardo Garcia Fuentes; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Ryan Cline; editing: Harvey Richards, Joan Hilty | Blossom; Bubbles; Buttercup; Mojo Jojo; Mayor; Professor Utonium; Sara Bellum (cameo) |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy | Bubbles; Blossom; Buttercup |
| 9 | Remote Controlled | comic story | 22 | script: Chuck Kim; pencils: Mike Manley; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Ryan Cline; editing: Harvey Richards, Joan Hilty | Bubbles; Buttercup; Blossom; Dr. Blowtop; Professor Utonium; Mayor; Mojo Jojo (cameo) |
| 10 | - | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Bubbles; Blossom; Buttercup; Mayor; Sara Bellum |
| 11 | Mayor, May I? | comic story | 22 | script: Jennifer Moore, Sean Carolan; pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Ryan Cline; editing: Harvey Richards, Joan Hilty | Buttercup; Blossom; Bubbles; Mayor; Sara Bellum |
| 12 | Creature at Large! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Bubbles; Buttercup; Blossom |
| 13 | Creature at Large! | comic story | 16 | script: Chris Savino; pencils: Cynthia Morrow; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Ryan Cline; editing: Harvey Richards, Joan Hilty | Buttercup; Blossom; Bubbles; Mayor; Truck Driver Bob |
| 14 | Blowing Bubbles | comic story | 6 | script: Amy Keating Rogers; pencils: Ricardo Garcia Fuentes; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Ryan Cline; editing: Harvey Richards, Joan Hilty | Bubbles; Buttercup; Blossom; Mayor |
| 15 | Here's Pie in Your Eye! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Blossom, Bubbles, Buttercup |
| 16 | Rogue Clowns | comic story | 22 | script: Abby Denson; pencils: Ricardo Garcia Fuentes; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Ryan Cline; editing: Harvey Richards, Joan Hilty | Blossom, Bubbles, Buttercup |
| 17 | - | blank page(s) | 1 | | |
| 18 | - | illustration | 1 | letters: typeset | |