| 0 | Mad Roasts Comedy | cover | 1 | pencils: Tom Richmond; inks: Tom Richmond; colors: Tom Richmond | |
| 1 | - | credits, title page | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | |
| 2 | A Mad Look at Practical Jokes | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Luth; letters: Sergio Aragonés | |
| 3 | If Different Comedians Told The Same Joke (There's a Fly in My Soup...) | comic story | 3 | script: Russ Cooper; pencils: Mort Drucker; inks: Mort Drucker | Robin Williams; George Carlin; David Letterman; Rodney Dangerfield; Sam Kinison; Dana Carvey [as the Church Lady]; Yakov Smirnoff; Steven Wright |
| 4 | Spy Vs Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 5 | MAD's 12 Surefire Tips for Stand-Up Comics | comic story | 3 | script: Jeff Kruse; pencils: Rick Tulka; inks: Rick Tulka; colors: Ryan Flanders | Chad Gorpley |
| 6 | Mad's Updated Practical Joke Catalog | comic story | 5 | script: Al Jaffee, Diane Riccobene; pencils: Al Jaffee; inks: Al Jaffee | |
| 7 | The First Comedian on Mars | comic story | 1 | script: Eddie Pepitone, Karen Simmons; pencils: Eddie Pepitone; inks: Eddie Pepitone; colors: Eddie Pepitone | |
| 8 | Swinefilled | comic story | 5 | script: Stan Hart; pencils: Mort Drucker; inks: Mort Drucker | |
| 9 | Joke Set-ups That Don’t Need a Punchline | comic story | 1 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 10 | Comedians in Cars Getting Arrested | comic story | 3 | script: Reid Harrison, Gene Laufenberg; pencils: Anton Emdin; inks: Anton Emdin; colors: Anton Emdin | |
| 11 | Practical Joke Items Guaranteed to Put the “Fun” Back in Funerals | comic story | 3 | script: Dick DeBartolo, Frank Santopadre; pencils: Kevin Pope; inks: Kevin Pope | |
| 12 | Pop Culture That Didn't Make It Into... Ready Player One | comic story | 2 | script: Brian Posehn; pencils: Peter Bagge; inks: Peter Bagge | |
| 13 | Spy Vs Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | |
| 14 | Stink Lines Through Art History | photo story | 3 | script: Maria Bamford; pencils: Scott Marvel Cassidy; inks: Scott Marvel Cassidy; colors: Scott Marvel Cassidy | |
| 15 | Mad's Practical Joke Catalogue for Courtrooms | comic story | 2 | script: Desmond Devlin; pencils: Al Jaffee; inks: Al Jaffee | |
| 16 | The Monotonous Mrs. Mazel | comic story | 5 | script: Charlie Kadau; pencils: Sam Viviano; inks: Sam Viviano | |
| 17 | Outside a Novelty Shop | comic story | 3 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 18 | Mad Novelty Items for Practical-Joker Jocks | comic story | 3 | script: Paul Peter Porges; pencils: Jack Davis; inks: Jack Davis | |
| 19 | If Different Comedians Told The Same Joke | comic story | 2 | script: Harrison Greenbaum; pencils: Jason Seiler; inks: Jason Seiler | Dane Cook; Jay Leno; Larry the Cable Guy; Bill Maher; Carlos Mencia; Ellen DeGeneres; Lewis Black |
| 20 | Jack & Jim Gaffigan's Easy 15-Step Recipe for Avocado Toast | comic story | 2 | script: Jack Gaffigan, Jim Gaffigan; pencils: Sam Viviano; inks: Sam Viviano | |
| 21 | Patton Oswalt's Waffle House Hidden Hashbrown Menu / Emo Philips' Believe It or Don't | comic story | 0.8 | script: Patton Oswalt, Emo Philips; pencils: Scott Bricher, Anton Emdin, Rick Tulka; inks: Scott Bricher, Anton Emdin, Rick Tulka | Julius Caesar, Abraham Lincoln, Richard Nixon |
| 22 | What Is the Worst Part of the Job for Some Comedians? | activity | 1 | script: Johnny Sampson; pencils: Johnny Sampson; inks: Johnny Sampson; colors: Johnny Sampson; letters: Johnny Sampson | |