| 0 | Special Christmas Seal Issue | cover | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |
| 1 | Life Insurance? I'd Rather Play the Horses! | photo story | 1 | pencils: Lester Krauss; inks: Lester Krauss | |
| 2 | Departments | table of contents | 1 | pencils: various (see Notes); inks: various (see Notes); letters: typeset | |
| 3 | Random Samplings of Reader Mail | letters page | 1 | script: Al Feldstein | |
| 4 | Send Christmas Greetings All Year 'Round! | promo (ad from the publisher) | 0.65 | pencils: Lester Krauss; inks: Lester Krauss | |
| 5 | Fill Those Stockings with "Greasy MAD Stuff" | promo (ad from the publisher) | 0.35 | letters: typeset | |
| 6 | Future Singing TV Commercials | comic story | 4 | script: Frank Jacobs; pencils: Jack Rickard; inks: Jack Rickard | |
| 7 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 8 | Celebrities' Nightmares | comic story | 2 | script: Don Reilly; pencils: Mort Drucker; inks: Mort Drucker | John F. Kennedy, Nikita Khrushchev, Frank Sinatra, Mao Zedong |
| 9 | Some Mad Hints for the Coming Xmas Season | comic story | 3 | script: Dick De Bartolo; pencils: Bob Clarke; inks: Bob Clarke | Robert E. Lee |
| 10 | The Epicure | comic story | 2 | script: Edgar A. Guest; pencils: Don Martin; inks: Don Martin | |
| 11 | More Movie Dialogue We'd Like to Hear | comic story | 1 | script: Harry Purvis; pencils: George Woodbridge; inks: George Woodbridge | Pat O'Brien [as Father Connolly]; Johnny Weissmueller [as Tarzan]; Maureen O'Sullivan [as Jane Porter] |
| 12 | Trademarks Resulting From Future Mergers | comic story | 2 | script: Don Reilly; pencils: Wallace Wood; inks: Wallace Wood | |
| 13 | A Mad Guide to Hypnotism | comic story | 6 | script: Phil Hahn; pencils: Bob Clarke; inks: Bob Clarke | Alfred E. Neuman |
| 14 | Jabber-Whacky | text story | 1 | script: Isabelle Di Caprio; pencils: George Woodbridge; inks: George Woodbridge | Alice; Queen of Hearts; Tweedledee (or Tweedledum); White Rabbit; Cheshire Cat; Carpenter; Mock Turtle; Mad Hatter; Humpty Dumpty; White King; playing card soldier |
| 15 | - | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy, The White Spy |
| 16 | The Lighter Side of Cops | comic story | 4 | script: David Berg; pencils: David Berg; inks: David Berg | |
| 17 | 3 Sure Fire Methods of Getting a Job | comic story | 2 | script: Mickey Rose; pencils: Joe Orlando; inks: Joe Orlando | |
| 18 | - | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy, The White Spy |
| 19 | The Academy Awards for Home Movies | comic story | 5 | script: Stan Hart; pencils: Mort Drucker; inks: Mort Drucker | Irving Waterhouse; Lyman Fumbler; Jack Gluck; Diane Picknoze; Theresa Mutz; Selma Needleman; Sally Ann Freem; Sanford Gass; Mildred Twill; Claude Fibula; Aunt Zelda; Aunt Ida; Fran Akers; Walt Akers; Jerry De Fuccio; Ginny De Fuccio; Clara Englehard; Donny Portnoy; Lenny Rupp; Harry Hartnett; Carl B |
| 20 | A Mad Look at Santa | comic story | 2 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | Santa Claus |
| 21 | - | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy, The White Spy |
| 22 | Modern Teacher | comic story | 7 | script: Larry Siegel; pencils: George Woodbridge; inks: George Woodbridge | Jimmy Hoffa |
| 23 | An Early Morning Bathroom Scene | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 24 | Are You Haunted by the Ghost of Christmas Presents? | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); letters: typeset | |
| 25 | I'm the Guy Who Puts Eight Great Tomatoes in that Little Bitty Can!! | illustration | 1 | pencils: Lester Krauss; inks: Lester Krauss; colors: Lester Krauss | |