| 0 | Yes We Can't | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson | Alfred E. Neuman [as Alfred E. Obama] |
| 2 | Departments | table of contents | 1 | pencils: various; inks: various; letters: typeset | Alfred E. Neuman; Monroe; Amy Winehouse; Indiana Jones; Black Spy; Trumpkin |
| 3 | Random Samplings of Reader Mail | letters page | 3.67 | script: John Ficarra | Alfred E. Neuman; Kal Penn |
| 4 | - | credits, title page | 0.33 | letters: typeset | |
| 7 | The Fundalini Pages | comic story | 3 | script: Dick DeBartolo, Jacob Lambert; pencils: Rick Tulka, Tom Cheney, Gary Hallgren; inks: Rick Tulka, Tom Cheney, Gary Hallgren | Calvin; Steve Jobs; Miley Cyrus; Grant Dullard; Don Sequitur |
| 8 | The 46-Year-Old Political Virgin | illustration | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | Barack Obama |
| 9 | Inadiaper Jones and the Kingdom of the Creative Dry Spell | comic story | 5 | script: Arnie Kogen; pencils: Hermann Mejía; inks: Hermann Mejía | Inbanana Jones; Ireeka Shpilkis; Muck Wilson; Marryin Ravingwood; Mack McHeel; Charles Steerforth; Lox Loxley |
| 11 | A Mad Look At Summer Fun | comic story | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 12 | Millions of Trees Gave Their Lives For These Books | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | |
| 13 | Amy | comic story | 2 | pencils: Gary Hallgren; inks: Gary Hallgren | Amy Winehouse |
| 14 | Planet TAD!!!!! | comic story | 2 | script: Tim Carvell | Rex [Mr. Kensington]; Hamburger Helper Hand |
| 15 | Spy Vs. Spy | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | Black Spy; White Spy |
| 16 | In Stores This Week! | comic story | 1 | script: Darren Johnson | |
| 17 | Monroe and...The New Phone | comic story | 4 | script: Anthony Barbieri; pencils: Tom Fowler; inks: Tom Fowler; colors: Carl Peterson | Monroe; Monroe's mother; Monroe's father; Monroe's grandfather; Phone Company Frank; Walter; Mr. Bines; Cameron Shnivle |
| 18 | An Important Message From MAD's Director of Business & Development | promo (ad from the publisher) | 1 | script: Jeffrey Lozenge | Jeffrey Lozenge |
| 19 | When The Recession Hits Funeral Homes | comic story | 2 | script: Teresa Burns Parkhurst; pencils: Teresa Burns Parkhurst; inks: Teresa Burns Parkhurst; letters: Teresa Burns Parkhurst | |
| 20 | MAD Heads For The Hills Outtakes | comic story | 2 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | |
| 21 | The MAD World of Travel | comic story | 3 | script: Stan Sinberg; pencils: Marc Hempel; inks: Marc Hempel | |
| 22 | No Country For Old Man | illustration | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | John McCain |
| 23 | MADKids On Sale Now! | promo (ad from the publisher) | 2 | script: various; pencils: various; inks: various; letters: typeset | JAck Black; Alfred E. Neuman; White Spy Jr.; Black Spy Jr. |
| 24 | The Chronic-Ills of Yawnia Prince Thespian | comic story | 4 | script: Dick DeBartolo; pencils: Mort Drucker; inks: Mort Drucker | Loosely; Deadmund; Snoozen; Peeper; Prince Thespian; Pumpkin; Triflehunter; Redo-Cheep; King MyAss; Grumpy (cameo); Dopey (cameo); Aslan; George W. Bush (cameo) |
| 25 | What The Heck Is The Difference? | activity | 1 | pencils: Don Martin; inks: Don Martin | |
| 26 | What Horrific Disaster Is Leaving Many Experts Feeling Bewildered And Helpless? | activity | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | Amy Winehouse |
| 27 | Drawn-Out Dramas | comic story | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |