| 0 | This Is the End of Mad | cover | 1 | pencils: Kelly Freas; inks: Kelly Freas; colors: Kelly Freas; letters: Kelly Freas | Alfred E. Neuman |
| 1 | See the Difference Color TV Makes... | comic story | 1 | script: Al Jaffee; pencils: Kelly Freas; inks: Kelly Freas; colors: Kelly Freas | |
| 2 | Wash and Wish... or... Wash and Bewitch? | comic story | 1 | pencils: Kelly Freas; inks: Kelly Freas | |
| 3 | Departments | foreword, introduction, preface, afterword | 1 | pencils: various; inks: various; letters: typeset | |
| 4 | Mad Goes on Record | promo (ad from the publisher) | 0.33 | pencils: ? (photo); inks: ? (photo); letters: typeset | Alfred E. Neuman |
| 5 | If You Have the Feeling Mankind Is Doomed, Read | promo (ad from the publisher) | 0.17 | pencils: ? (photo); inks: ? (photo); letters: typeset | |
| 6 | Random Samplings of Reader Mail | letters page | 1 | script: Albert B. Feldstein, Charles Johnson, Sheldon Mayer | Scribbly Jibbet; Moxie Cowznofsky |
| 7 | They're Sweeping the Country! | promo (ad from the publisher) | 0.17 | pencils: Norman Mingo; inks: Norman Mingo | Alfred E. Neuman |
| 8 | Don't Look Like an April Fool | promo (ad from the publisher) | 0.33 | pencils: George Woodbridge; inks: George Woodbridge | |
| 9 | Sunday Evening Television Roulette | comic story | 4 | script: Gary Belkin; pencils: Mort Drucker; inks: Mort Drucker | Gene Rayburn; Steve Allen; Ed Sullivan; Eydie Gorme; Jane Mansfield; Brett Maverick; Henny Youngman; Senior Wences; Mickey Mantle; The Four Aces; Ben Hogan; The Belgian Congo Ballet Company |
| 10 | The Suicide | comic story | 2 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 11 | Authentic Sounds in Stereo | comic story | 2 | script: Tom Koch; pencils: Wally Wood; inks: Wally Wood | |
| 12 | Modern Auto Accidents | comic story | 3 | script: Al Jaffee; pencils: Bob Clarke; inks: Bob Clarke | |
| 13 | How High-Class Magazines Can Use Low-Class Pictures | comic story | 3 | script: Frank Jacobs; pencils: Joe Orlando; inks: Joe Orlando | Irving Finster; Zelda Zitzlaff |
| 14 | Western Weapons of the Future | comic story | 2 | script: Larry Siegel; pencils: George Woodbridge; inks: George Woodbridge | |
| 15 | The Hidden Persuaders Become the Hip Persuaders | comic story | 3 | script: Gary Belkin; pencils: Wally Wood; inks: Wally Wood | Miles Davis; Dizzy Gillespie |
| 16 | How to Choose and Train Your Master | comic story | 4 | script: Frank Jacobs, Robert Margroff; pencils: George Woodbridge; inks: George Woodbridge | |
| 17 | Mad's Modern Handy Phrase Book for the American Tourist | text article | 3 | script: Sy Reit; pencils: George Woodbridge; inks: George Woodbridge | |
| 18 | Modern Architecture | comic story | 3 | script: Al Jaffee; pencils: Bob Clarke; inks: Bob Clarke | Frank Lloyd Wrighteous; Mies Van Der Roebuck; Alfred E. Neuman |
| 19 | On Choosing a Book | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 20 | If Famous Authors Wrote the Comics | comic story | 4 | script: Frank Jacobs; pencils: Wally Wood; inks: Wally Wood | William Shakespeare; Donald Duck; Huey; Dewey; Louie; Pauline Poodle; Dick Tracy; Flattop; Pruneface; Charlie Brown; Lucy Van Pelt; Linus Van Pelt; Schroeder; Snoopy; Pigpen; Hans; Fritz; The Captain; Rex Morgan; Little Orphan Annie; Sandy; Big Daddy Warbucks; Cousin Asp; Dennis the Menace; Nancy; S |
| 21 | Mad's Cut-Rate Success Symbols | comic story | 2 | script: Sy Reit; pencils: Joe Orlando; inks: Joe Orlando | |
| 22 | Movies Are Emptier Than Ever | comic story | 3 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 23 | TV Ads We'd Like to See | comic story | 1 | pencils: Mort Drucker; inks: Mort Drucker | |
| 24 | The Happy Endings Weren't So Happy | comic story | 4 | script: Sy Reit; pencils: Bob Clarke; inks: Bob Clarke | Hansel; Gretel; Derrence Clarow; Beauty; Irving Prince [The Beast]; Jack; Sleeping Beauty; Prince Charming; Little Red Riding Hood |
| 25 | On Picking Flowers | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 26 | For the First Time in Your Life... Feel Really Mad! | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); letters: typeset | Leonard Brenner |
| 27 | Mad Daffynitions | text story | 0 | letters: typeset | |