| 0 | We Screw Around with Friends | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson; colors: Mark Fredrickson | Alfred E. Neuman |
| 1 | Departments | table of contents | 1 | pencils: various; inks: various; colors: various; letters: typeset | |
| 2 | - | letters page | 3 | pencils: various; inks: various; colors: various; letters: typeset | |
| 3 | Carpool the Video Game | comic story | 2 | script: David Shayne; pencils: Scott Bricher, Timothy Shamey; inks: Scott Bricher, Timothy Shamey; colors: Scott Bricher | |
| 4 | Trashing Places | comic story | 7 | script: Dick DeBartolo; pencils: Tom Richmond; inks: Tom Richmond | Paging Diva; Gendereve; Flank; Dung; Don; Clare; Alfred E. Neuman (cameo); Hans; Helen |
| 5 | Closet Homophobes... | comic story | 3 | script: Butch D'Ambrosio; pencils: Keith Seidel; inks: Keith Seidel | |
| 6 | Signs That Friends Just Doesn't Give a Damn Anymore | comic story | 3 | script: Dennis Snee; pencils: Ray Alma; inks: Ray Alma | |
| 7 | Where Do They Get Off? Vol. II | comic story | 2 | script: Stan Sinberg; pencils: Tom Bunk; inks: Tom Bunk | |
| 8 | Duke Bissell's Tales of Undisputed Interest | comic story | 1 | script: P. C. Vey; pencils: P. C. Vey; inks: P. C. Vey; letters: P. C. Vey | |
| 9 | Unintended Bumper Messages | photo story | 2 | script: Jeff Kruse; pencils: Irving Schild; inks: Irving Schild; colors: Irving Schild | |
| 10 | More Ridiculous Friends Spinoffs We're Sure to See... | comic story | 2 | script: Greg Leitman; pencils: Drew Friedman; inks: Drew Friedman | |
| 11 | Monroe and... the Downloads | comic story | 4 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray; letters: Bill Wray | |
| 12 | - | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper; colors: Peter Kuper | The Black Spy, The White Spy |
| 13 | Mad's Make Your Own Movie Sequel | photo story | 1 | script: Jonathan Bresman | |
| 14 | A Mad Look at Fashion | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 15 | Duke Bissell's Tales of Undisputed Interest | comic story | 1 | script: P. C. Vey; pencils: P. C. Vey; inks: P. C. Vey; letters: P. C. Vey | |
| 16 | Things We Might Have Seen Had Jerry Springer Run for the Senate | comic story | 3 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 17 | Non-Sports Over/Under Bets | comic story | 1 | script: Mike Mikula; pencils: Rick Tulka; inks: Rick Tulka | |
| 18 | Seebrisket | comic story | 5 | script: Arnie Kogen; pencils: Mort Drucker; inks: Mort Drucker | Jeff Bridges [as Jowls Howeird]; Tobey Maguire [as Bled Dullard]; Chris Cooper [as Tomb Stiff]; Seebrisket; Elizabeth Banks [as Marvella Howeird]; William H. Macy [as Tipp Topp McMuffin]; Eddie Jones [as Mr. Dibbles]; Worn Animal |
| 19 | Some Like It Shot | comic story | 1 | script: Duck Edwing; pencils: Duck Edwing; inks: Duck Edwing | |
| 20 | What Form of Terrorism Does the Department of Homeland Security Appear Helpless to Prevent? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |