| 0 | In This Issue… We Squish Spider-Man! | cover | 1 | script: Ray Alma; pencils: Mort Drucker; inks: Mort Drucker | |
| 1 | Spider-Sham | comic story | 7 | script: Dick DeBartolo; pencils: Tom Richmond; inks: Tom Richmond | Alfred E. Neuman (cameo); Tobey Maguire [as Spider-Sham [Peeper Porker]]; Richard Simmons (cameo); James Franco [as Harried Osbored]; Kirstin Dunst [as MT]; Stan Lee (cameo); Cliff Robertson [as Uncle Been Porker] (death); Willem Dafoe [as Green Gasman [Mr. Osbored]] (death) |
| 2 | 12 Signs You May Be Too Wired | comic story | 2 | script: Mike Snider; pencils: Tom Bunk; inks: Tom Bunk | |
| 3 | Duke Bissell’s Tales of Undisputed Interest | comic story | 2 | script: P. C. Vey; pencils: P. C. Vey; inks: P. C. Vey | |
| 4 | Mad Examines Some Examples of Misdirected Patriotism | comic story | 2 | script: Charlie Kadau; pencils: Paul Coker; inks: Paul Coker | |
| 5 | Drama on Page 20 | comic story | 1 | script: Michael Gallagher; pencils: John Caldwell; inks: John Caldwell | |
| 6 | The 21 Hottest Internet Rumors Regarding Star Wars Episode II: Attack of the Clones | comic story | 5 | script: Arie Kaplan; pencils: Hermann Mejía; inks: Hermann Mejía | |
| 7 | Monroe and… the Love Lesson | comic story | 4 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray | |
| 8 | - | comic story | 2 | script: Michael Gallagher; pencils: Peter Kuper; inks: Peter Kuper | |
| 9 | The Lighter Side of... | comic story | 4 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg; colors: Digital Chameleon | Roger Kaputnik |
| 10 | What is a Terrorist? | comic story | 3 | script: Barry Liebmann; pencils: Drew Friedman; inks: Drew Friedman | |
| 11 | A Mad Look at Spider-Man | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 12 | Six Feet Blunder | comic story | 5 | script: Charlie Kadau; pencils: Angelo Torres; inks: Angelo Torres | Frances Conroy [as Root Fishhead]; Michael C. Hall [as Gayvid Fishhead]; Peter Krause [as Late Fishhead]; Rachel Griffiths [as Benda]; Jeremy Sisto [as Silly]; Freddy Rodriguez [as Deaderico]; Matthew St. Patrick [as Officer Teeth]; Lauren Ambrose [as Scare Fishhead]; Richard Jenkins [as Nathenal Fi |
| 13 | The Mad Bulletin Board | text story | 1 | letters: typeset | |
| 14 | Where Are Extreme Acts of Mistreatment Tolerated By the American Public? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |