| 0 | We Squeeze Malcolm in the Middle! | cover | 1 | pencils: Roberto Parada; inks: Roberto Parada | |
| 1 | Malcontent in the Muddle | comic story | 6 | script: Desmond Devlin; pencils: Tom Richmond; inks: Tom Richmond | Frankie Muniz [as Malcontent]; Jane Kaczmarek [as Mom]; Bryan Cranston [as Howl]; Christopher Masterson [as Frantic]; Erik Per Sullivan [as Gooey]; Timothy Q. Mouse (cameo); Justin Berfield [as Reek]; Craig Lamar Traylor [as Skeevy]; Alfred E. Neuman (cameo) |
| 2 | A Mad Look at the Library | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 3 | A Kid’s Guide to Writing Letters | comic story | 3 | script: Ryan Pagelow | |
| 4 | - | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | |
| 5 | Monroe and… the Special Delivery | comic story | 4 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray | |
| 6 | A Bloody Mess | comic story | 1 | script: Michael Gallagher; pencils: Tom Bunk; inks: Tom Bunk | |
| 7 | Unbearable | comic story | 4 | script: Dick DeBartolo; pencils: Angelo Torres; inks: Angelo Torres | Bruce Willis [as Deadly Dull]; Robin Wright Penn [as Ordinarily Dull]; Stan Marsh (cameo); Kenny McCormick (cameo); Eric Cartman (cameo); Kyle Broflovski (cameo) |
| 8 | 10 Sure Signs You’re Suffering From March Madness | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 9 | Mad's Celebrity Cause-Of-Death Betting Odds | comic story | 1 | script: Mike Snider; pencils: Hermann Mejía; inks: Hermann Mejía | Eminem |
| 10 | Home Despot Sales Circular | comic story | 3 | script: Jeff Kruse, Russ Cooper; pencils: George Woodbridge; inks: George Woodbridge | |
| 11 | 2000: The Year in Film | photo story | 2 | script: Desmond Devlin; pencils: AP/Wide World; inks: AP/Wide World | |
| 12 | Other Fashion Brand Names That Are Actually Acronyms | comic story | 1 | script: Mike Snider; pencils: Rick Tulka; inks: Rick Tulka | |
| 13 | The Lighter Side of... | comic story | 4 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | Roger Kaputnik |
| 14 | Cheesy Angles | comic story | 6 | script: Dick DeBartolo; pencils: Hermann Mejía; inks: Hermann Mejía | Cameron Diaz [as Naughty]; Sam Rockwell [as Eric Knockoff]; Tim Curry [as Roger Boreman]; |
| 15 | What Major Challenge is Confronting Many of Today’s Teens? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |