| 0 | - | cover | 1 | pencils: Richard Williams; inks: Richard Williams; colors: Richard Williams | Alfred E. Neuman |
| 1 | - | letters page | 1 | script: Nick Meglin | |
| 2 | Warped Games | comic story | 4 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Matthew Broderick [as Mavin]; Dabney Coleman [as McKidTricks]; Ally Sheedy [as Juniper] |
| 3 | Bedsheet Signs We'll Never See on TV | comic story | 2 | script: Tom Koch; pencils: Bob Clarke; inks: Bob Clarke | |
| 4 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 5 | Macho Is... | comic story | 3 | script: Tom Koch; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 6 | One Morning in the Dungeon Room | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 7 | The Lighter Side of… | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 8 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 9 | Mad's Multiple Choice TV Scene Test | comic story | 3 | script: Paul Peter Porges; pencils: Paul Peter Porges; inks: Paul Peter Porges | |
| 10 | One Afternoon in the School Room | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 11 | Mad's All-Inclusive "Monday Night Football" Betting Pool | comic story | 2 | pencils: Jack Davis; inks: Jack Davis | |
| 12 | Famous Quotations …and How the People Back Then Reacted to Them | comic story | 3 | script: Frank Jacobs; pencils: Harry North; inks: Harry North | Abraham Lincoln; Patrick Henry; Franklin D. Roosevelt; Henry M. Stanley; Admiral Lawrence; John Kennedy; Benjamin Franklin; Will Rogers; Richard Nixon; Admiral Perry; Neil Armstrong |
| 13 | Asinine to Five | comic story | 5 | script: Dick DeBartolo; pencils: Angelo Torres; inks: Angelo Torres | Rachel Dennison [as Dolly Lee]; Valerie Curtin [as Juicy]; Rita Moreno [as Violent]; Jean Marsh [as Razz]; Peter Bonerz [as Mr. Hard] |
| 14 | Mad's All-Inclusive Do-It-Yourself "Jingle Bells" | text story | 2 | script: Frank Jacobs | |
| 15 | A Mad History of Communication | comic story | 5 | script: Larry Siegel; pencils: George Woodbridge; inks: George Woodbridge | |
| 16 | Mad's Aptitude Test Number Two: Will You Make a Good Teacher? | text story | 1 | script: Frank Jacobs; pencils: George Woodbridge; inks: George Woodbridge | |
| 17 | You Know You're In a Second Marriage When... | comic story | 2 | script: Lloyd Gola; pencils: Lloyd Gola; inks: Lloyd Gola | |
| 18 | Psycho, Too | comic story | 4 | script: Dick DeBartolo; pencils: Mort Drucker; inks: Mort Drucker | Anthony Perkins [as Abnormal Baits]; Vera Miles [as Liar Looney]; Meg Tilly [as Merry] |
| 19 | One Evening in the Living Room | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 20 | What Kind of Weather Report Can Chill You To the Bone? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 21 | - | comic story | 1 | script: Don Edwing; pencils: Don Martin; inks: Don Martin; colors: Don Martin | |