| 0 | - | cover | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin; colors: Don Martin | Alfred E. Neuman |
| 1 | More Hysteria Repeats Itself! | promo (ad from the publisher) | 1 | letters: ?; typeset | |
| 2 | - | table of contents | 1 | letters: typeset | |
| 3 | - | letters page | 0.67 | script: Jerry De Fuccio | |
| 4 | - | statement of ownership | 0.25 | script: William Gaines | |
| 5 | Why Kill Yourself? | promo (ad from the publisher) | 0.6 | pencils: Paul Coker; inks: Paul Coker | |
| 6 | 8 "James Bomb" Bomb Movies | comic story | 9 | script: Arnie Kogen; pencils: Mort Drucker; inks: Mort Drucker | Sean Connery [as James Bomb]; Lois Maxwell [as Miss Pennymoney]; Ursula Andress [as Honey Roper]; Joseph Wiseman [as Dr. No-No]; Lotte Lenya [as Rosa Klobb]; Gert Frobe [as Goldfingerbowl]; Harold Sakata [as Oddbomb]; Honor Blackman [as Tushy Galore]; Claudine Auger [as Dominique]; George Lazybee [a |
| 7 | The Mad Bowling Primer | comic story | 3 | script: Larry Siegel; pencils: Jack Davis; inks: Jack Davis | |
| 8 | A Mad Look at Tyrants | comic story | 2 | script: Arnoldo Franchioni; pencils: Arnoldo Franchioni; inks: Arnoldo Franchioni | |
| 9 | The Lighter Side of Cold Weather | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 10 | One Dark Night in a Laboratory | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 11 | Sure-Fire Ticket Deterrents for Frustrated Drivers | comic story | 2 | script: Dick De Bartolo; pencils: Bob Clarke; inks: Bob Clarke; letters: Bob Clarke | |
| 12 | Mad Sequels to Famous Poems | comic story | 6 | script: Tom Koch; pencils: George Woodbridge; inks: George Woodbridge | |
| 13 | "I Want You" Posters Starring Today's Celebrities | comic story | 3 | script: Frank Jacobs; pencils: Jack Rickard; inks: Jack Rickard | |
| 14 | Mad Visits the "Realistic School of Medicine" | comic story | 4 | script: Larry Siegel; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 15 | Biplane Buffoonery | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 16 | Unavoidable Exercises for the Urban Dweller | comic story | 2 | script: Frank Jacobs; pencils: Al Jaffee; inks: Al Jaffee | |
| 17 | One Night in a Police Station | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 18 | The Dulltons | comic story | 6 | script: Lou Silverstone; pencils: Angelo Torres; inks: Angelo Torres | Richard Thomas [as John-Mop Dullton]; Ralph Waite [as John-Paw Dullton]; Michael Learned [as Olive-Drab Dullton]; Ellen Corby [as Grandma Dullton]; Will Geer [as Grandpa Dullton]; David W. Harper [as Jim-Boob Dullton]; Judy Norton [as Merry-Girl Dullton]; Mary Elizabeth McDonough [as Errandgirl Dull |
| 19 | What Is Believing in Honest Politicians Like? | activity | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | Richard Nixon |
| 20 | - | illustration | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 21 | Heads...You Lose! | illustration | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | |