| 0 | Special Polluted Issue of Mad | cover | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |
| 1 | Why Not Have the Next Issue Sent Directly to Your Home? | promo (ad from the publisher) | 0.5 | pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 2 | Lover's Story | comic story | 7 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Ryan O'Neal [as Oscar Wallet IV]; Ali McGraw [as Penny Cowsnofskibumsteinpastafazoola]; Ray Milland [as Oscar Wallet III]; Katharine Balfour [as Mrs. Wallet] |
| 3 | The Electronic War Game | comic story | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | Major Hawks; Private Doves |
| 4 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 5 | This Is America... | comic story | 4 | script: Max Brandel | Richard Nixon; Spiro Agnew; Alfred E. Neuman; Neil Armstrong; Robert Kennedy |
| 6 | The Lighter Side of the "Now Look" | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 7 | The Very First Musical Instrument | comic story | 2 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 8 | The Mad "Effluent Society" Pollution Primer | comic story | 3 | script: Sy Reit; pencils: Angelo Torres; inks: Angelo Torres | Alfred E. Neuman |
| 9 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 10 | Mad Interviews a Typical "Middle American" Family | comic story | 5 | script: Lou Silverstone; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | Dick Cavett |
| 11 | Recruiting Posters Through History | comic story | 3 | script: Paul Peter Porges; pencils: George Woodbridge; inks: George Woodbridge | |
| 12 | A Mad Peek Behind the Scenes at a Resort Hotel | comic story | 3 | script: Larry Siegel; pencils: Bob Clarke; inks: Bob Clarke | |
| 13 | A Mad Look at Amusement Parks | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 14 | One Fine Day a Million Years Ago | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 15 | Reality Street | comic story | 6 | script: Dick DeBartolo; pencils: Jack Davis; inks: Jack Davis | Roscoe Orman [as Gorgon]; Bob McGrath; Loretta Long; Curt; Ornery; Cake Monster; Grover; Ookie; Dirty Bird; Scary |
| 16 | What's Always Been the Favorite Method For Camouflaging Military Activity? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 17 | The Four Horsemen of the Metropolis | illustration | 1 | script: Frank Jacobs; pencils: Jack Thurston; inks: Jack Thurston; colors: Jack Thurston | |