| 0 | The Second Annual "You'll Go 'Ape' Over This Issue of Mad" Issue of Mad | cover | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo | Alfred E. Neuman |
| 1 | Some Mad Suggestions for Other 'Ridiculous Ad Images' | comic story | 2 | script: Phil Hahn, Jack Hanrahan; pencils: Bob Clarke; inks: Bob Clarke | The Esso/Humble Tiger |
| 2 | In the Delicatessen | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 3 | BrandXed | comic story | 5 | script: Lou Silverstone; pencils: Mort Drucker; inks: Mort Drucker | Chuck Conners [as Jason McNutt]; David Janssen [as Dr. Richard Kimble] |
| 4 | Achieving Personal Success in Crime | comic story | 2 | script: Tom Koch; pencils: George Woodbridge; inks: George Woodbridge | |
| 5 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 6 | The Lighter Side of Elementary School | comic story | 4 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 7 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 8 | National Perspirer | comic story | 5 | script: Larry Siegel; pencils: Al Jaffee; inks: Al Jaffee | |
| 9 | Mad's "Lifetime - - People" Chart | comic story | 2 | script: Frank Jacobs; pencils: John Putnam; inks: John Putnam | |
| 10 | In the Optometrist's Waiting Room | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 11 | ABC TV's Wide World of Sports | comic story | 5 | script: Al Jaffee; pencils: George Woodbridge; inks: George Woodbridge | Jim McKay; Chris Schenkel; Bill Fleming |
| 12 | New Board Games We'd Really Like to See | comic story | 3 | script: Patrick McGivern; pencils: Bob Clarke; inks: Bob Clarke | |
| 13 | In the Haberdashery | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 14 | The Typical Luxury Apartment House Ad | comic story | 4 | script: Larry Siegel; pencils: Joe Orlando; inks: Joe Orlando | |
| 15 | Boy Scouts Vs. Little Old Ladies | comic story | 2 | script: Don Edwing; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 16 | Spy Vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 17 | Bubby Lake Missed (by a mile) | comic story | 6 | script: Stan Hart; pencils: Mort Drucker; inks: Mort Drucker | Carol Linley [as Mrs. Lake]; Lawrence Olivier [as Superintendent Nuthouse]; Keir Dullea [as Speedy]; Noel Coward [as Oscar]; Jiggs (cameo); Charlie Brown (cameo); Otto Preminger |
| 18 | How You Too Can Make a Fortune in the Booming Ski Business | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 19 | The Television Studio | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |