| 0 | - | cover | 1 | pencils: Tom Taggart; inks: Tom Taggart; colors: Tom Taggart | |
| 1 | The Big Book of Martyrs | credits, title page | 2 | pencils: Donald David; inks: Donald David | |
| 2 | Table of Contents | table of contents | 2 | letters: typeset | |
| 3 | To Be a Martyr | comic story | 4 | script: John Wagner; pencils: George Freeman; inks: George Freeman | |
| 4 | They Walked with Jesus | foreword, introduction, preface, afterword | 1 | script: John Wagner | |
| 5 | Voice in the Wilderness | comic story | 4 | script: John Wagner; pencils: Michael Cherkas; inks: Michael Cherkas | St. John the Baptist |
| 6 | Suffer the Children | comic story | 3 | script: John Wagner; pencils: Chris Schenck; inks: Chris Schenck | The Holy Innocents |
| 7 | The Rock | comic story | 4 | script: John Wagner; pencils: Jim Fern; inks: Jim Fern | St. Peter |
| 8 | The First Martyr | comic story | 3 | script: John Wagner; pencils: Joe Orlando; inks: Joe Orlando | St. Stephen |
| 9 | Apostle of India | comic story | 4 | script: John Wagner; pencils: Gregory Benton; inks: Gregory Benton | St. Bartholomew |
| 10 | The Great Evangelist | comic story | 4 | script: John Wagner; pencils: Dan Lawlis; inks: Dan Lawlis | St. Paul |
| 11 | Of Myth and Men | comic story | 5 | script: John Wagner; pencils: Rick Geary; inks: Rick Geary | The Apostles |
| 12 | The Age of Persecution | foreword, introduction, preface, afterword | 1 | script: John Wagner | |
| 13 | While Rome Burned | comic story | 3 | script: John Wagner; pencils: Gahan Wilson; inks: Gahan Wilson | |
| 14 | A Sea of Faith | comic story | 3 | script: John Wagner; pencils: Bob Fingerman; inks: Bob Fingerman | St. Clement |
| 15 | The Willing Martyr | comic story | 2 | script: John Wagner; pencils: Flint Henry; inks: Flint Henry | St. Ignatius |
| 16 | On Grounds of Christianaity | comic story | 2 | script: John Wagner; pencils: Michael Dubisch; inks: Michael Dubisch | St. Ptolomaeus; St. Lucius |
| 17 | The Cult of Saints | comic story | 2 | script: John Wagner; pencils: Frank Quitely; inks: Frank Quitely | St. Polycarp |
| 18 | Testament of Courage | comic story | 4 | script: John Wagner; pencils: Shary Flenniken; inks: Shary Flenniken | St. Perpetua; St. Felicity |
| 19 | Burning Devotion | comic story | 2 | script: John Wagner; pencils: Steve Lieber; inks: Steve Lieber | St. Laurence |
| 20 | Boy Wonder | comic story | 4 | script: John Wagner; pencils: Tayyar Ozkan; inks: Tayyar Ozkan | St. Vitus |
| 21 | Lamb of God | comic story | 3 | script: John Wagner; pencils: Trina Robbins; inks: Trina Robbins | St. Agnes |
| 22 | Healing Hands | comic story | 4 | script: John Wagner; pencils: Graham Manley; inks: Graham Manley | St. Blaise |
| 23 | The High and the Low | foreword, introduction, preface, afterword | 1 | script: John Wagner | |
| 24 | The Grave Gardener | comic story | 3 | script: John Wagner; pencils: Kirk-Albert Etienne; inks: Kirk-Albert Etienne | St. Phocas |
| 25 | The Slave Pope | comic story | 3 | script: John Wagner; pencils: Jeff Parker; inks: Jeff Parker | St. Callistus |
| 26 | Noble Heart | comic story | 4 | script: John Wagner; pencils: Win Mortimer; inks: Win Mortimer | St. Agatha |
| 27 | Women's Liberator | comic story | 3 | script: John Wagner; pencils: Dave DeVries; inks: Dave DeVries | St. Wilgefortis |
| 28 | Good King-Bad King | comic story | 4 | script: John Wagner; pencils: Joe Phillips; inks: Joe Phillips | St. Wenceslas |
| 29 | Murder in the Cathedral | comic story | 4 | script: John Wagner; pencils: Randy DuBurke; inks: Randy DuBurke | St. Thomas Becket |
| 30 | The Arrogance of Kings | comic story | 4 | script: John Wagner; pencils: Joe Sacco; inks: Joe Sacco | St. Thomas More; St. John Fisher |
| 31 | Cruel Britannia | comic story | 4 | script: John Wagner; pencils: Graham Higgins; inks: Graham Higgins | |
| 32 | Soldiers of the Cross | foreword, introduction, preface, afterword | 1 | script: John Wagner | |
| 33 | The Good Pagan | comic story | 3 | script: John Wagner; pencils: Brett Lewis; inks: Brett Lewis | St. Alban |
| 34 | Piercing Devotion | comic story | 4 | script: John Wagner; pencils: Ted Slampyak; inks: Ted Slampyak | St. Sebastian |
| 35 | The Thundering Legion | comic story | 3 | script: John Wagner; pencils: Steve Mannion; inks: Steve Mannion | |
| 36 | The Ultimate Sacrifice | comic story | 3 | script: John Wagner; pencils: Charles Drost; inks: Charles Drost | St. Oswald |
| 37 | The Reluctant Soldier | comic story | 4 | script: John Wagner; pencils: Roger Langridge; inks: Roger Langridge | St. Edmund |
| 38 | Hammer of the Heathens | comic story | 3 | script: John Wagner; pencils: Rafael Kayanan; inks: Rafael Kayanan | St. Olaf |
| 39 | Against the Mongol Horde | comic story | 3 | script: John Wagner; pencils: Eric Shanower; inks: Eric Shanower | St. Michael of Chernigov |
| 40 | Maid of Orleans | comic story | 4 | script: John Wagner; pencils: Colleen Doran; inks: Colleen Doran | St. Joan of Arc |
| 41 | The Stuff of Legend | foreword, introduction, preface, afterword | 1 | script: John Wagner | |
| 42 | Dragonslayer | comic story | 4 | script: John Wagner; pencils: Donald David; inks: Donald David | St. George |
| 43 | Time Enough for Love | comic story | 3 | script: John Wagner; pencils: Joe Staton; inks: Joe Staton | St. Valentine |
| 44 | Christ-Bearer | comic story | 4 | script: John Wagner; pencils: Rick Parker; inks: Rick Parker | St. Christopher |
| 45 | Portrait of a Saint | comic story | 3 | script: John Wagner; pencils: Peter Gross; inks: Peter Gross | St. Rhipsime |
| 46 | The 11,000 Virgins | comic story | 3 | script: John Wagner; pencils: Chuck Wojtkiewicz; inks: Chuck Wojtkiewicz | St. Ursula |
| 47 | Extreme Prejudice | comic story | 3 | script: John Wagner; pencils: Brian Buniak; inks: Brian Buniak | The Boy Martyrs |
| 48 | Wheels on Fire | comic story | 4 | script: John Wagner; pencils: Robin Smith; inks: Robin Smith | Catherine of Alexandria |
| 49 | The Phantom Martyr | comic story | 3 | script: John Wagner; pencils: Kathryn Hyatt; inks: Kathryn Hyatt | Philomena |
| 50 | Remains of the Day | comic story | 2 | script: John Wagner; pencils: Gordon Purcell; inks: Gordon Purcell | St. Protus; St. Hyacinth |
| 51 | Unto This Day | foreword, introduction, preface, afterword | 1 | script: John Wagner | |
| 52 | On Savage Shores | comic story | 7 | script: John Wagner; pencils: Dan Burr; inks: Dan Burr | |
| 53 | Crucifixion at Nagasaki | comic story | 3 | script: John Wagner; pencils: Lennie Mace; inks: Lennie Mace | St. Paul Miki |
| 54 | Cruel Practices | comic story | 3 | script: John Wagner; pencils: Galen Showman; inks: Galen Showman | |
| 55 | Fear No Evil | comic story | 3 | script: John Wagner; pencils: Tom Sutton; inks: Tom Sutton | |
| 56 | The Good Child | comic story | 3 | script: John Wagner; pencils: Marie Severin; inks: Marie Severin | St. Maria Goretti |
| 57 | Auschwitz Priest | comic story | 4 | script: John Wagner; pencils: D'Israeli D'Emon Draughtsman; inks: D'Israeli D'Emon Draughtsman | St. Maximilian Kolbe |
| 58 | A Case for Canonization | comic story | 4 | script: John Wagner; pencils: David Lloyd; inks: David Lloyd | Edith Stein |
| 59 | Tomorrow's Martyrs | comic story | 3 | script: John Wagner; pencils: Steve Carr; inks: Steve Carr | |
| 60 | Biographies | text article | 2 | letters: typeset | |
| 61 | Bibliography | text article | 1 | letters: typeset | |
| 62 | Copyright Information | text article | 1 | letters: typeset | |
| 63 | Index of Saints | text article | 1 | | |