| 0 | Superman Battles the Mightiest Men in the Universe! | cover | 1 | pencils: Rich Buckler; inks: Frank Giacoia; letters: Gaspar Saladino | Superman; The Parasite; Solomon Grundy; Galactic Golem; Vartox; The Sand Superman |
| 1 | Best of DC -- Superman versus the Mightiest Men in the Universe | table of contents | 1 | script: E. Nelson Bridwell | |
| 2 | Solomon Grundy Wins on a Monday! | comic story | 17 | script: Gerry Conway; pencils: José Luis García-López; inks: Bob Oksner | Superman; Solomon Grundy (villain); SKULL (cameo); Steve Lombard; Terri Cross |
| 3 | Power of the Parasite! | comic story | 14 | script: Jim Shooter; pencils: Al Plastino; inks: Al Plastino | Parasite; Superman; Lois Lane; Perry White |
| 4 | The Ultimate Battle | recap | 2 | pencils: Curt Swan; inks: Murphy Anderson | |
| 5 | The Ultimate Battle! | comic story | 22 | script: Denny O'Neil; pencils: Curt Swan; inks: Murphy Anderson | Quarrm-Demon (villain); Superman; Stewpot; Gemmi; Jimmy Olsen; Sand creature; Wonder Woman [as Diana Prince]; I-Ching |
| 6 | The Man Who Murdered the Earth! | comic story | 18 | script: Len Wein; pencils: Curt Swan; inks: Murphy Anderson | Lex Luthor (villain); the Galactic Golem (intro); Superman; Lois Lane |
| 7 | Mystery Mission to Metropolis! Chapter One: The Mystery Unravels... | comic story | 10 | script: Cary Bates; pencils: Curt Swan; inks: Bob Oksner | |
| 8 | Mystery Mission to Metropolis! Chapter Two: ...And the Mission Begins! | comic story | 10 | script: Cary Bates; pencils: Curt Swan; inks: Bob Oksner | |
| 9 | More Mighty Men of the Universe | text article | 3 | script: E. Nelson Bridwell | |
| 10 | - | promo (ad from the publisher) | 1 | pencils: Brian Bolland; inks: Brian Bolland | |
| 11 | 5 Cosmos-Shaking Clashes! | foreword, introduction, preface, afterword | 1 | pencils: Rich Buckler; inks: Frank Giacoia; letters: Gaspar Saladino | Superman; The Parasite; The Galactic Golem; The Sand Superman; Vartox; Solomon Grundy |