| 0 | - | cover | 1 | pencils: Curt Swan; inks: George Klein; letters: Ira Schnapp | Supergirl; Superman [Clark Kent] |
| 1 | - | table of contents | 1 | pencils: Jim Mooney; inks: Jim Mooney | |
| 2 | Part 1: The Unknown Supergirl! | comic story | 12.5 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney | Supergirl [Linda Lee]; Superman; Krypto; Linda Lee robot; Jerro; Lori Lemaris; Tough Tommy |
| 3 | Steve Ditko... Strikes Again! | promo (ad from the publisher) | 0.33 | letters: Gaspar Saladino | |
| 4 | Part Two: Supergirl's Secret Enemy! | comic story | 10 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney | Supergirl [Linda Danvers]; Lesla-Lar (villain); Superman; Edna Danvers; Lex Luthor; Streaky |
| 5 | Part 3: Trapped in Kandor! | comic story | 12 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney; letters: Milt Snapinn | Supergirl [Linda Danvers] (brief origin); Superman [also appears as Clark Kent]; Lex Luthor; Lesla-Lar (villain); Fred Danvers; Edna Danvers; Zor-El (flashback); Perry White (cameo); Martha Kent (flashback; cameo); Jonathan Kent (flashback; cameo) |
| 6 | Pow! | promo (ad from the publisher) | 0.5 | pencils: Neal Adams; inks: Neal Adams; letters: Ira Schnapp | |
| 7 | Milestones in Supergirl's Life | text article | 1 | script: E. Nelson Bridwell | |
| 8 | Part 4: The Three Red "K" Perils! | comic story | 10.5 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney | Supergirl; Mr. Mxyzptlk; Fred Danvers; Edna Danvers; Superman; Dick Malverne; Rolf Von Holtz; Conway Tremaine |
| 9 | - | in-house column | 1 | pencils: Gil Kane, Jack Sparling; inks: Murphy Anderson, Jack Sparling | |
| 10 | Part 5: The Super-Mermaid! | comic story | 4 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney; letters: Milt Snapinn | Supergirl [Linda Danvers]; Krypto; Jerro; Lenora Lemaris; Lori Lemaris; Superman; Fred Danvers; Edna Danvers |
| 11 | Part 6: The World's Greatest Heroine! | comic story | 11 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney | Superman; Supergirl; Lex Luthor; Fred Danvers; Edna Danvers; Zor-El (flashback); John F. Kennedy; Jerro; Lenora Lemaris; Dick Malverne |
| 12 | There's a New Kind of Superman Comin'! | promo (ad from the publisher) | 1 | letters: Gaspar Saladino | Superman (silhouette) |
| 13 | Part 7: The Infinite Monster! | comic story | 11 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney | Supergirl; Legion of Super-Heroes [Lightning Lad; Cosmic Boy; Saturn Girl; Brainiac 5]; President John F. Kennedy; Jacqueline Kennedy; Lyndon B. Johnson; Superman; Professor Hartz; Dick Malverne; Mrs. Hart |