| 0 | 21 Down | cover | 1 | pencils: Joe Jusko; inks: Joe Jusko; colors: Joe Jusko | |
| 1 | - | blank page(s) | 1 | | |
| 2 | 21 Down: The Conduit | credits, title page | 1 | pencils: Jesús Saiz; inks: Jesús Saiz; colors: Jesús Saiz | |
| 3 | Credits | credits, title page | 2 | | |
| 4 | By Rights This Book Should Not Exist. | foreword, introduction, preface, afterword | 2 | script: Garth Ennis | |
| 5 | 21 Down | comic story | 4 | script: Jimmy Palmiotti, Justin Gray; pencils: Jesús Saiz; inks: Jimmy Palmiotti; colors: Paul Mounts; letters: Comicraft | |
| 6 | Simple Kind of Life | cover reprint (on interior page) | 1 | pencils: Joe Jusko; inks: Joe Jusko; colors: Joe Jusko | Mickey Rinaldi; Preston Kills |
| 7 | 21 Down | comic story | 22 | script: Jimmy Palmiotti, Justin Gray; pencils: Jesús Saiz; inks: Jimmy Palmiotti; colors: Paul Mounts; letters: Comicraft | Mickey Rinaldi; Preston Kills; Robert Kills; Mad Dog Duggin |
| 8 | Mickey | character profile | 1 | pencils: Jesús Saiz; inks: Jesús Saiz | |
| 9 | I Like to Wear Sheep's Clothing | cover reprint (on interior page) | 1 | pencils: Joe Jusko; inks: Joe Jusko; colors: Joe Jusko | Mickey Rinaldi; Preston Kills |
| 10 | 21 Down | comic story | 22 | script: Jimmy Palmiotti, Justin Gray; pencils: Jesús Saiz; inks: Jimmy Palmiotti; colors: Paul Mounts; letters: Comicraft | Mickey Rinaldi; Preston Kills; Robert Kills; Harmony Peterson |
| 11 | Mad Dog / Harmony | character profile | 1 | pencils: Jesús Saiz; inks: Jesús Saiz | |
| 12 | I'm Not Sick, but I'm Not Well | cover reprint (on interior page) | 1 | pencils: Joe Jusko; inks: Joe Jusko; colors: Joe Jusko | Mickey Rinaldi; Harmony Peterson |
| 13 | 21 Down | comic story | 22 | script: Jimmy Palmiotti, Justin Gray; pencils: Jesús Saiz; inks: Jimmy Palmiotti; colors: Paul Mounts; letters: Comicraft | Mickey Rinaldi; Preston Kills; Robert Kills; Harmony Peterson; Agent Ishikawa; Agent Kristin Sizemore |
| 14 | Scarsdale | illustration | 1 | pencils: Jesús Saiz; inks: Jesús Saiz | |
| 15 | Don't Stand Alone in These Strangest of Times | cover reprint (on interior page) | 1 | pencils: Joe Jusko; inks: Joe Jusko; colors: Joe Jusko | |
| 16 | 21 Down | comic story | 22 | script: Jimmy Palmiotti, Justin Gray; pencils: Jesús Saiz; inks: Jimmy Palmiotti; colors: Paul Mounts; letters: Comicraft | |
| 17 | Clyde / Robert | character profile | 1 | pencils: Jesús Saiz; inks: Jesús Saiz | |
| 18 | Distance from One Into the Other | cover reprint (on interior page) | 1 | pencils: Joe Jusko; inks: Joe Jusko; colors: Joe Jusko | |
| 19 | 21 Down | comic story | 22 | script: Jimmy Palmiotti, Justin Gray; pencils: Jesús Saiz; inks: Jimmy Palmiotti; colors: Paul Mounts; letters: Comicraft | |
| 20 | Creepy Priest | character profile | 1 | pencils: Jesús Saiz; inks: Jesús Saiz | |
| 21 | End of Night | cover reprint (on interior page) | 1 | pencils: Joe Jusko; inks: Joe Jusko; colors: Joe Jusko | |
| 22 | 21 Down | comic story | 22 | script: Jimmy Palmiotti, Justin Gray; pencils: Jesús Saiz; inks: Jimmy Palmiotti; colors: Paul Mounts; letters: Comicraft | |
| 23 | Preston | character profile | 1 | script: Justin Gray; pencils: Jesús Saiz; inks: Jesús Saiz | |
| 24 | Transitions | cover reprint (on interior page) | 1 | pencils: Joe Jusko; inks: Joe Jusko; colors: Joe Jusko | |
| 25 | 21 Down | comic story | 22 | script: Jimmy Palmiotti, Justin Gray; pencils: Jesús Saiz; inks: Jimmy Palmiotti; colors: Paul Mounts; letters: Comicraft | |
| 26 | - | blank page(s) | 1 | | |
| 27 | 21 Down | promo (ad from the publisher) | 1 | letters: typeset | |